Document Type : Original Research


1 Dept. Of Pediatric Infectious, Shahrekord University Of Medical Sciences, Shahrekord, Iran

2 Dept. Of Medical Parasitology, Kerman University Of Medical Science, Kerman, Iran

3 Dept. Of Social Medicine, Shahrekord University Of Medical Sciences, Shahrekord, Iran

4 Dept. Of Infectious Disease, Shahrekord University Of Medical Sciences, Shahrekord, Iran

5 Dept. Of Pathology, Kerman University Of Medical Science, Kerman, Iran

6 General Physician, Shahrekord University Of Medical Sciences, Shahrekord, Iran


Background and Objectives: An increasing number of tularemia was reported in all over the world. This infection is characterized by different clinical syndromes that can be considered in differential diagnosis of infectious disease. Despite effective antibiotics against Francisella tularensis, this infection is still as one of the agent of mortality and disability among infectious disease.The aim of this study was investigation of seroepidemiological of F. tuleransis among children between 2-18 years old in a risky zone in Iran.
Methods: This cross-sectional, laboratory-based study in two distinct villages Saragha seyed and Khoye in Chaharmahal va bakhtiari Province involved 183 children, adolescents who had no sign and symptom of disease and were screened for tularemia immunoglobulins G (IgG), using the ELISA-based quantitative assay.
Results: In general, from 183 children 11 persons (6%) were seropositive, compared with 172 persons (94%) were seronegative.
Conclusion: According to the high prevalence of antibodies against F. tularensis in this study, this infection must be considered as differential diagnosis of infectious disease in suspect patients.


1. Colquhoun DJ, Duodu S. Francisella infections in farmed and wild aquatic organisms. Vet Res 2011;42(45):1-15.
2. Foley JE, Nieto NC. Tularemia. Vet Microbiol 2010;140(3-4):332-8.
3. Keim P, Johansson A, Wagner DM. Molecular epidemiology, evolution, and ecology of Francisella. Ann N Y Acad Sci 2007;1105(1):30-66.
4. Eliasson H, Broman T, Forsman M, Bäck E. Tularemia: current epidemiology and disease management. Infect Dis Clin North Am. 2006;20(2):289-311.
5. Splettstoesser W, Piechotowski I, Buckendahl A, Frangoulidis D, Kaysser P, Kratzer W, et al. Tularemia in Germany: the tip of the iceberg? Epidemiol Infect 2009;137(5):736-43.
6. Clark DV, Ismailov A, Seyidova E, Hajiyeva A, Bakhishova S, Hajiyev H, et al. Seroprevalence of Tularemia in Rural Azerbaijan. Vector Borne Zoonotic Dis2012;12(7):558-63.
7. Arata A, Chamsa M, Farhang-Azad A, Meščerjakova I, Neronov V, Saidi S. First detection of tularaemia in domestic and wild mammals in Iran. Bull World Health Organ 1973;49(6):597-603.
8. Gutiérrez M, Orduna A, Dueñas A, Bratos M, Almaraz A, Alamo R, et al. Prevalence of antibodies against Francisella tularensis in Castilla y Leon (Spain) before 1997. Med Clin (Barc) 2003;120(3):97-8.
9. Weinstein RA, Singh K. Laboratory-acquired infections. Clin Infect Dis 2009;49(1):142-7.
10. Gurcan S. Francisella tularensis and tularemia in Turkey. Mikrobiyol Bul 2007;41(4):621-36.
11. Titball RW, Sjostedt A. Francisella tularensis: An Overview-Ongoing research progresses toward understanding pathogenesis and virulence mechanisms, and may help lead to an improved vaccine. ASM News-Am Soc Microbiol 2003;69(11):558-63.
12. Mignani E, Palmieri F, Fontana M, Marigo S. Italian epidemic of waterborne tularaemia. Lancet 1988;2(8625):1423.
13. Gallego L, Junquera L, Palacios JJ, de Vicente JC. Cervical tularaemia in a non-endemic area. Med Oral Patol Oral Cir Bucal 2009;14(4):180-2.
14. Saliba GS, Harmston FC, Diamond BE, Zymet CL, Goldenberg MI, Chin TDY. An outbreak of human tularemia associated with the American dog tick, Dermacentor variabilis. Am J Trop Med Hyg 1966;15(4):531-8.
15. Helvacı S, Gedikoğlu S, Akalın H, Oral H. Tularemia in Bursa, Turkey: 205 cases in ten years. Eur J Epidemiol 2000;16(3):271-6.
16. Kantardjiev T, Ivanov I, Velinov T, Padeshki P, Popov B, Nenova R, et al. Tularemia outbreak, Bulgaria, 1997–2005. Emerg Infect Dis 2006;12(4):678-80.
17. Karimi Y. First human's Tularemia case in Iran. Iran Med Org J 1981;8(8):134-41.