Iranian Journal of Pathology

Low Grade Appendiceal Mucinous Neoplasm – A Case Series A Silent Threat with Deadly Consequences

Document Type : Case Reports

Authors

S.J. John Joseph Hemnath 1, 2
Shanmugapriya M 1, 2
Suresh R 1, 2
Paleri Madhumita 1, 2
Lokeshwari V 1, 2
Eswari V 1, 2

1 Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamilnadu, India

2 Meenakshi Academy of Higher Education and Research, Chennai, India

https://doi.org/10.30699/ijp.2025.2055124.3421
Abstract
Background & Objective: Our study was mainly aimed at identifying the cause, clinical course of the disease, its most dreaded complication pseudomyxoma peritonei and spread to adjacent structures. We have used IHC techniques to know the origin of the tumor where both appendix and ovary were involved.
Case Presentation: We have listed out and discussed in detail 5 cases, each of which have a different clinical course and variation in staging, grading and prognosis. One of the cases had mucin deposits in the ovary, for which IHC was done to confirm the origin of the tumor. Some of the findings were incidental and in others presence of mucin content in the appendix lumen raised clinical suspicion of spread to peritoneum and adjacent structures. Grading and staging is of prime importance as it determines the prognosis and management of the patient respectively.
Conclusion: A ruptured or perforated appendix must warrant for an immediate suspicion of pseudomyxoma peritonei which when untreated can lead to mucinous neoplasms in adjacent organs like ovary and colon. Pseudomyxoma Peritonei (PMP) with simultaneous appendix and ovarian neoplasm should be treated as primary appendiceal tumour. Grading and staging of mucinous neoplasm of appendix and Pseudomyxoma Peritoneii needs a unified approach for standardized diagnostic reporting.

Keywords

Appendiceal Neoplasms
Pseudomyxoma Peritonei
Immunohistochemistry

Subjects

Copyright © 2025. This is an open-access article distributed under the terms of the Creative Commons Attribution- 4.0 International License which permits Share, copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, even commercially.

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Iranian Journal of Pathology
Volume 20, Issue 3
Summer 2025
Pages 335-343

  • Receive Date 05 March 2025
  • Revise Date 06 May 2025
  • Accept Date 06 June 2025

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