Iranian Journal of Pathology

The Link Between High Sensitivity Troponin T Levels and Outcomes Among Patients with Congestive Heart Failure: A Systematic Review and Meta-Analysis Study

Document Type : Systematic Review

Authors

Alireza Abdollahi 1
Zohreh Nozarian 2
Samaneh Salarvand 1
Elham Pourebrahimi 1

1 Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

2 Department of Pathology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

https://doi.org/10.30699/ijp.2025.2057561.3440
Abstract
Background & Objective: High-sensitivity cardiac troponin T (hs-cTnT) has emerged as a critical biomarker in cardiovascular diseases, particularly in congestive heart failure (CHF). This systematic review and meta-analysis aimed to assess the association between hs-cTnT levels and clinical outcomes in patients with CHF.
Methods: A comprehensive literature search was performed across multiple databases to identify studies evaluating the relationship between hs-cTnT levels and clinical outcomes in CHF. Eligible studies reported hazard ratios (HRs) or odds ratios (ORs) for all-cause mortality, cardiovascular mortality, or cardiovascular hospitalization.
Results: Elevated hs-cTnT levels were significantly associated with adverse outcomes. The pooled HR and OR for all-cause mortality were 1.70 (95% CI, 1.49–1.94) and 6.19 (95% CI, 3.88–9.86), respectively. For cardiovascular mortality, the pooled HR was 1.59 (95% CI, 1.38–1.83) and the pooled OR was 6.87 (95% CI, 3.93–12.01). For cardiovascular hospitalization, the pooled HR was 1.56 (95% CI, 1.42–1.70) and the pooled OR was 4.32 (95% CI, 2.22–8.39).
Conclusion: Elevated hs-cTnT levels are strongly associated with an increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular hospitalization in patients with CHF. These findings highlight the prognostic value of hs-cTnT in the clinical management of heart failure.

Keywords

High-Sensitivity Troponin T
Congestive Heart Failure
Mortality
Hospitalization
Clinical Outcomes

Subjects

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Iranian Journal of Pathology
Volume 20, Issue 3
Summer 2025
Pages 245-256

  • Receive Date 10 April 2025
  • Revise Date 01 May 2025
  • Accept Date 13 May 2025

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