Iranian Journal of Pathology

Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study

Document Type : Short Communication

Authors

Nasser Malekpour Alamdari 1
Iman Ansari 2
Mohammad Ali Azizi Nadian 2
Mahdiyeh Sadat Seyyedi 1
Maryam Abbasi 1, 2

1 Critical Care Quality Improvement Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 General Surgery Department, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

https://doi.org/10.30699/ijp.2024.2026732.3290
Abstract
Background & Objective: Obesity is a growing public health problem worldwide. Bariatric surgery is considered the safest and most effective therapeutic option, although it is associated with various metabolic and neurohormonal consequences. This study aims to evaluate the effect of sleeve gastrectomy (SG) on hypothyroidism within one year following surgery.
Methods: In this single-center prospective cross-sectional study, patients with morbid obesity who were candidates for SG were included. Body mass index (BMI), levothyroxine dosage, and thyroid function tests were compared at baseline and 12 months after surgery.
Results & Conclusion: Patients’ BMI, levothyroxine dosage, TSH, and T4 levels decreased significantly after surgery (P<0.0001). The effect of SG on T3 levels was not statistically significant. The results of this study demonstrate that SG can significantly improve thyroid function tests in patients with morbid obesity and reduce their need for levothyroxine within one year following surgery. 

Keywords

Bariatric surgery
Hypothyroidism
Morbid obesity
Sleeve gastrectomy

Subjects

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Iranian Journal of Pathology
Volume 20, Issue 1
Winter 2025
Pages 133-137

  • Receive Date 17 April 2024
  • Revise Date 09 June 2024
  • Accept Date 26 June 2024

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