Iranian Journal of Pathology

Transitional Metaplasia of Renal Collecting Ducts in Vesicoureteral Reflux and Chronic Pyelonephritis: An Immunohistochemical Study of a Case and Review of the Literature

Document Type : Case Reports

Authors

Naser Tayyebi Meibodi 1
Salman Soltani 2
Farnaz Torabian 3

1 Department of Pathology, Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

https://doi.org/10.30699/ijp.2023.1998769.3087
Abstract
The capability of the urinary tract to undergo metaplastic changes such as squamous, intestinal, glandular, mucinous, or ciliated epithelium in renal pelvis has been previously reported, which hypothetically is due to the mechanical irritation of the transitional epithelium. However, transitional metaplasia is a rare presentation in the collecting ducts. The aim of this paper was to report this type of extremely rare metaplasia and to inform pathologists that they may encounter this kind of metaplasia. A 25-year-old man, a known case of vesicoureteral reflux (VUR), referred to the Imam Reza Hospital; affiliated to the Mashhad University of Medical Sciences, for bilateral nephrectomy. Gross evaluation of bilateral nephrectomy specimens showed atrophic kidneys and dilated pelvicalyceal systems. The light microscopic evaluation showed transitional metaplasia in the background of chronic pyelonephritis, confirmed by GATA3 nuclear immunohistochemical stain.  In this study, we presented a rare case of a renal collecting duct with transitional epithelial lining replacing the normal epithelium as a metaplastic change, with the hypothesis that previous medical history including VUR, or hemodialysis could be the trigger for the metaplastic change, which should be confirmed by further studies.

Keywords

Chronic renal failure
Kidney collectingducts
Metaplasia
Vesicoureteral reflux

Subjects

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Iranian Journal of Pathology
Volume 18, Issue 4
Autumn 2023
Pages 480-483

  • Receive Date 03 April 2023
  • Revise Date 25 August 2023
  • Accept Date 16 September 2023

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