Iranian Journal of Pathology

Lymphoepithelial – Like Carcinoma with Papillary Transitional Cell Carcinoma of the Urinary Bladder Associated with Carcinoma in situ Changes of the Urothelium; A Case Report and Review of Literature

Document Type : Case Reports

Authors

Yahya Attaran 1
Simin Moghdam 2
Ahmad Monabati 3
Reza Sarkeshikian 4

1 M.D, FCAP, Assistant professor of Pathology, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

2 M.D, Department of Pathology, Beheshti Hospital, Shiraz, Iran

3 M.D, Professor of Pathology, Department of Pathology and Hematology Research Center, Shiraz University of Medical sciences, Shiraz, Iran

4 M.D, Pasteur Pathobiology Laboratory, Shiraz, Iran

https://doi.org/10.30699/ijp.14.2.156
Abstract
Lymphoepithelial - like carcinoma, is rarely recognized in the urinary bladder and less commonly occurs with papillary transitional cell carcinoma i.e. mixed pattern. Also, less uncommon is the occurrence of carcinoma in situ changes in the adjacent urothelium of these tumors. Here, a case of lymphoepithelial – like carcinoma and papillary transitional cell carcinoma associated with carcinoma in situ changes of urothelium of the urinary bladder has been reported the prognosis of this type of malignancy as well as its management will be discussed. Meanwhile, immunohistochemical stains have been carried out to differentiate it from lymphoma of the urinary bladder and the findings will be discussed.

Keywords

Urinary Bladder
like carcinoma
Carcinoma in situ

Subjects

  1. Amin MB, Histological variants of urothelial carcinoma: diagnostic, therapeutic and prognostic implications. Modern Pathology. (2009)22 , 96 - 118. https://doi.org/10.1038/modpathol.2009.26
  2. Amin MB, Ro JY, Lee KM, Ordóñez NG, Dinney CP, Gulley ML, et al , Lymphoepithelial – Like carcinoma of the urinary bladder Am J Surg Pathol. 1994; ( 5 ) : 466-473 . https://doi.org/10.1097/00000478-199405000-00005
  3. Beltrán AL, Luque RJ, Vicioso L, Anglada F, Requena MJ, Quintero A, et al. Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases, Virchows Archiv. 2001; 438: 552-557 .
    https://doi.org/10.1007/s004280000378
  4. Hardan P, Eardly I, Joyce AD, Cytokeratin 20 as an objective marker of urothelial dysplasia, British Journal of Urology International.1996; 78: 870 -875. https://doi.org/10.1046/j.1464-410X.1996.23511.x
  5. HOLMANG S, BORGHEDE G, Johansson SL. Bladder carcinoma with lymphoepithelioma-like differentiation: a report of 9 cases. The Journal of urology. 1998 Mar;159(3):779-82. https://doi.org/10.1016/S0022-5347(01)63727-3
  6. Izquierdo-Garcia FM, Garcia-Diez F, Fernandez I, Perez-Rosado A, Saez A, Suarez-Vilela D, et al. Lymphoepithelial – Like carcinoma of the urinary bladder three cases with clinicopathological and P 53 Protein expression study , Virchows Archiv. 2004; 444 : 420-425 . https://doi.org/10.1007/s00428-004-1000-x
  7. Kakizoe T, Matumoto K, Nishio Y, Ohtani M, Kishi K, Significance  of carcinoma in situ and dysplasia in association with bladder cancer , The Journal of Urology. 1985; 133 (3) : 395 – 398. https://doi.org/10.1016/S0022-5347(17)48994-4
  8. Kessler ER, Amini A, Wilson SS, Breaker K, Raben D, La Rosa FG, et al. Lymphoepithelioma – Like carcinoma of the urinary bladder, Oncology Journal , Bladder Cancer. June 15 , 2015 .
  9. Mills SE, Greenson JK, Hornick JL, Longacre TA, Reuter VE Sternberg’s Diagnostic Surgical Pathology , 6th Edition , Wolters Kluwer Health , page 960 and 1183 .
  10. Pantelides NM, Ivaz SL, Falconer A, Hazell A, Winkler M, Hrouda D, et al. Lymphoepithelial – Like carcinoma of the urinary bladder : A case report and review of systemic treatment options , Urology Annals.  2012; ( 4 )45-47 .
    https://doi.org/10.4103/0974-7796.91626
  11. Porcaro AB, Gilioli E, Migliorini F, Antoniolli SZ, Iannucci A, Comunale L, Primary lymphoepithelial – Like carcinoma of the urinary bladder report of one case with review and update of literature after a pooled analysis of 43 cases , International Urology and Nephrology. 2003; 35 : 99-106.
    https://doi.org/10.1023/A:1025981106561
  12. Rosai J Rosai and Ackerman’s surgical pathology, 10ed. New York: Elsevier ; pages 297, 373, 599, 632, 636, 837, 951, 1205,  373, 599, 632, 636, 837, 951, 1205, 1296 and 1303.
  13. Stein JP, Lieskovsky G, Cote R, Groshen S, Feng AC, Boyd S, et al . Radical Cystectomy in the Treatment of Invasive Bladder Cancer  : Long-Term Result in 1,054 patients , Journal of Clinical Oncology. 2001; 19(3): 666-675 .
    https://doi.org/10.1200/JCO.2001.19.3.666
  14. Tamas EF, Nielsen ME, Schoenberg MP, Epstein JI. Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. Modern pathology. 2007 Aug; 20(8): 828. https://doi.org/10.1038/modpathol.3800823
  15. Williamson SR, Zhang S, Lopez-Beltran A, Shah RB, Montironi R, Tan PH, et al. Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. The American journal of surgical pathology. 2011 Apr 1;35(4):474-83. https://doi.org/10.1097/PAS.0b013e31820f709e
  16. Yoshino T, Ohara S, Moriyama H. Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature. BMC research notes. 2014 Dec;7(1):779. https://doi.org/10.1186/1756-0500-7-779
  17. Zukerberg LR, Harris NL, Young RH. Carcinomas of the urinary bladder simulating malignant lymphoma. A report of five cases. The American journal of surgical pathology. 1991 Jun;15(6):569-76.
    https://doi.org/10.1097/00000478-199106000-00005
Iranian Journal of Pathology
Volume 14, Issue 2
Spring 2019
Pages 156-164

  • Receive Date 25 August 2017
  • Revise Date 18 March 2018
  • Accept Date 28 February 2019

Home

Guide for Authors

Submit Manuscript

Contact Us