Iranian Journal of Pathology

Association of Helicobacter pylori Infection With Colon Cancer and Adenomatous Polyps

Document Type : Original Research

Authors

Fatemeh Teimoorian 1
Mohammad Ranaei 2
Karimollah Hajian-Tilaki 3
Javad Shokri Shirvani 4
Zeinab Vosough 1

1 Dept of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

2 Clinical Research Development Center, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran

3 Dept of Statistic and Epidmiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

4 Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Abstract
Background and objective: Helicobacter pylori infection is one of the most common chronic bacterial infections in the world, especially in the developing countries. This bacterium is the cause of many diseases such as lymphoma, gastritis, peptic ulcers, and stomach cancer. According to recent reports, H. pylori infection can potentially increase the risk of colon cancer. The current study aimed at investigating the association of H. pylori infection and the risk of colorectal cancer and adenomatous polyps.
Methods: The current study was conducted on 50 patients with colon cancer and adenomatous polyps as the case group and 100 subjects with no specific pathologies (i e, polyps, neoplasms, or inflammatory diseases) as the control group. Blood samples were collected from the patients in order to assess the presence of anti-Helicobacter pylori infection antibodies, and the serum titer levels of anti-Helicobacter pylori IgG and IgA antibodies were measured using indirect enzyme-linked immunosorbent assay (ELISA) and a kit procured by Pishtaz Teb Company (Iran).
Results: A total of 33 patients in the current study had adenomatous polyps and 17 had colon cancer. H. pylori infection (IgA >20 U/mL and IgG >10 U/mL) was significantly more prevalent in the patients with colon cancer and adenomatous polyps compared with the healthy controls (P= 0.003, P= 0.039, respectively).
Conclusion: The obtained results suggested that H. pylori infection can be considered as a risk factor for colon cancer and adenomatous polyps.

Keywords

Colorectal Neoplasms
Adenomatous Polyps
Helicobacter pylori Infection
Serum
Immunoglobulins

  • Receive Date 23 February 2017
  • Revise Date 02 November 2017
  • Accept Date 18 August 2018

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