Iranian Journal of Pathology

Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade

Document Type : Original Research

Authors

Hiva Saffar 1
Maryam Noohi 1
Seyed Mohammad Tavangar 1
Hana Saffar 2
Sima Azimi 1

1 Dept. of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Iran

2 Dept. of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Iran

https://doi.org/10.30699/ijp.13.1.45
Abstract
Background & Objective Angiogenesis is an essential component of tumor growth. Expression of PSMA on the neo-vasculature of many solid tumors, including glioblastoma multi-form, has been determined. The pattern of expression suggests that PSMA may play a functional role in angiogenesis.
Methods: expression of PSMA in different grades of brain glioma was evaluated by the immunohistochemistry method to determine the probable usefulness of anti-PSMA antibody as complementary target therapy in different grades of glioma.
Results: Overall, 72 cases of low (grade I and II) and high (grade III and IV) grade gliomas were evaluated for expression of PSMA. Positive PSMA staining was observed in 12 (33.3%) of high grade and 3 (8.3%) of low grade gliomas. Although, high grade tumors more commonly had positive result for PSMA (P value=0.009), the intensity of staining was significantly stronger in low-grade tumors (P value=0.009).
Conclusion: Expression of PSMA in different grades of glioma might provide a basis for further investigations focusing on selective target therapy in combination with the current standard care in all glioma grades, to improve treatment efficacy.

Keywords

Prostate-Specific Membrane Antigen
Glioma
Grade
Tumor angiogenesis
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Iranian Journal of Pathology
Volume 13, Issue 1
Winter 2018
Pages 45-53

  • Receive Date 29 December 2016
  • Revise Date 19 January 2017
  • Accept Date 13 February 2017

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