Iranian Journal of Pathology

Immunohistochemical Expression of Nuclear β-Catenin and STAT-6 in a Solitary Fibrous Tumor of the Soft Palate: A Case Report and Review of the Literature

Document Type : Case Reports

Authors

Ivonne A. Montes-Mojarro 1
Javier Baquera-Heredia 1
Juan Felipe Sanchez-Marle 2
Carlos Ortiz-Hidalgo 1

1 Surgical Pathology Department, The American British Cowdray Medical Center, Mexico city 01120, Mexico

2 Head and Neck Surgery Department, The American British Cowdray Medical Center, Mexico city 01120, Mexico

https://doi.org/10.30699/ijp.2017.25689
Abstract
The solitary fibrous tumors (SFT) are rare tumors in the head and neck region and there have been only 5 cases reported in the literature in the soft palate. The current paper presents a unique case of a 62-year-old male with TFS arising in the soft palate. The tumor was highly cellular, composed of bland looking haphazardly arranged spindle cells. The signal transducer and activator of transcription (STAT)-6 and nuclear β-catenin were reactive by immunohistochemistry (IHC). The current case highlights the importance of the STAT-6 and the β-catenin as IHC markers to make a differential diagnosis with other entities. In summary, the paper presents the first reported case of a SFT of the soft palate in a male patient with nuclear expression of STAT-6 and β-catenin.

Keywords

Solitary Fibrous Tumor (SFT)
Immunohistochemistry (IHQ)
Mesenchymal Tumors
Soft Palate
STAT-6
β-Catenin

Subjects

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Iranian Journal of Pathology
Volume 12, Issue 3
Summer 2017
Pages 281-285

  • Receive Date 17 March 2016
  • Revise Date 20 June 2016
  • Accept Date 05 February 2017

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