Iranian Journal of Pathology

Thyroid Stimulating Hormone, T3 and T4 Population-based Reference Range and Children Prevalence of Thyroid Dysfunction: First Report from South of Iran

Document Type : Original Research

Authors

Mansoureh Shokripour 1
Mohammad Hadi Imanieh 2
Saghar Garayemi 1
Navid Omidifar 1, 3
Babak Shirazi Yeganeh 1
Fadhil Althabhawee 1

1 Department of Pathology, School of Medicine Shiraz University of Medical Sciences, Shiraz, Iran

2 Gastroenterohepatology Research Center, Namazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3 Clinical Education Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30699/ijp.2022.541736.2812
Abstract
Background & Objective: The TSH reference range's validity affects the thyroid dysfunction diagnosis. The primary objective of this study is to determine the reference range, which is established according to age and region.
Methods: The data were collected retrospectively from people over the age of one who visited Motahari Clinic for routine health checkups between August 2017 and October 2019. TSH, T4, T3, personal drug usage, and thyroid history were collected. After excluding subjects with thyroid diseases and outliers, a list of 1392 participants was analyzed. Hormone intervals of men and women ≥1 year old have been determined using the non-parametric method.
Results: The non-disease subjects' TSH, T3, and T4 reference ranges were 0.64 to 5.94 lU/mL, 0.91 to 2.47 ng/dL, and 5.53 to 12.48 g/dL, respectively. According to this range, total thyroid dysfunction prevalence in our study in children was 8.94%. There was no significant difference between TSH, T4 level, and sex in the non-disease population (P=0.46 and 0.13, respectively), but there was a statistical difference between sex and T3 (P =0.03). Our study also illustrates that for subjects under 18 years old and above it, hormones (TSH, T3, T4) concentration is statistically different (P≤0.001).
Conclusion: We found a statistical difference between hormone values after and before age 18 (P=≤0.01); therefore, it is not appropriate to use the same reference range for children under age 18 and adults. There was male dominance in the population 1-18 years old. 

Keywords

Iran
Range
Reference
Reference range
TSH

Subjects

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Iranian Journal of Pathology
Volume 17, Issue 4
Autumn 2022
Pages 427-434

  • Receive Date 18 March 2022
  • Revise Date 21 June 2022
  • Accept Date 02 July 2022

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