Document Type : Case Reports
Authors
Clinical Research Development Unit, Kosar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract
Pure ovarian neuroendocrine tumors are very rare. Herein, we present a young Iranian woman with a pure primary ovarian neuroendocrine tumor.
A 26-year-old female presented with chronic abdominal pain and progressive constipation and was referred to the emergency room. Imaging findings confirmed a mass in the right adnexa. Following the resectional surgery of the ovarian mass, histopathological and immunohistochemistry results disclosed a mixed type of primary ovarian neuroendocrine tumor. The patient did not experience tumor recurrence afterward.
Due to the rarity and low prevalence of primary pure ovarian neuroendocrine tumors, the histopathologic diagnosis should be confirmed by an immunohistochemistry study.
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Main Subjects
- MalekZadeh M, Alahyari S, Sandoughdaran S, Zham H. Epidemiology of Neuroendocrine Tumors in an Iranian Population. Arch Iran Med. 2017;20(10):652-4.
- Kloppel G. Neuroendocrine Neoplasms: Dichotomy, Origin and Classifications. Visc Med. 2017;33(5):324-30. [DOI:10.1159/000481390] [PMID] [PMCID]
- Lopes Dias J, Cunha TM, Gomes FV, Calle C, Felix A. Neuroendocrine tumours of the female genital tract: a case-based imaging review with pathological correlation. Insights Imaging. 2015;6(1):43-52. [DOI:10.1007/s13244-014-0378-5] [PMID] [PMCID]
- Chun YK. Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review. J Pathol Transl Med. 2015. [PMID] [PMCID] [DOI:10.4132/jptm.2015.09.20]
- Lokuhetty D, White V, Watanabe R, Cree I. WHO classification of tumours of the digestive system. Lyon: International Agency for Research on Cancer. 2018.
- Salhi H, Laamouri B, Boujelbène N, Hassouna JB, Dhiab T, Hechiche M, Rahal K. Primary ovarian carcinoid tumor: a report of 4 cases. Int Surg J. 2017;4(8):2826-8. [DOI:10.18203/2349-2902.isj20173428]
- Halperin DM, Shen C, Dasari A, Xu Y, Chu Y, Zhou S, et al. Frequency of carcinoid syndrome at neuroendocrine tumour diagnosis: a population -based study. Lancet Oncol. 2017;18 (4):525-34. [DOI:10.1016/S1470-2045(17)30110-9]
- Noh HK, Kwon BS, Kim YH, Lee NK, Choi KU, Suh DS, et al. Peptide YY producing strumal carcinoid tumor of the ovary in a postmenopausal woman: a rare cause of chronic constipation. Obstet Gynecol Sci. 2017;60(6):602-7. [DOI:10.5468/ogs.2017.60.6.602] [PMID] [PMCID]
- Takeuchi M, Matsuzaki K, Uehara H. Primary carcinoid tumor of the ovary: MR imaging characteristics with pathologic correlation. Magn Reson Med Sci. 2011;10(3):205-9. [DOI:10.2463/mrms.10.205] [PMID]
- Lin F, Liu H. Immunohistochemistry in undifferentiated neoplasm/tumor of uncertain origin. Arch Pathol Lab Med. 2014;138(12): 1583-610. [DOI:10.5858/arpa.2014-0061-RA] [PMID]
- Heidarpour M, Tavanafar Z. Diagnostic utility of PAX8 in differentiation of mullerian from non-mullerian tumors. Adv Biomed Res. 2014;3:96. [DOI:10.4103/2277-9175.129366] [PMID] [PMCID]
- Chauhan A, Yu Q, Ray N, Farooqui Z, Huang B, Durbin EB, et al. Global burden of neuroendocrine tumors and changing incidence in Kentucky. Oncotarget. 2018;9(27):19245-54. [DOI:10.18632/oncotarget.24983] [PMID] [PMCID]
- Huang C, Hong MK, Ding DC. A review of ovary torsion. Ci Ji Yi Xue Za Zhi. 2017;29(3):143-7. [DOI:10.4103/tcmj.tcmj_55_17] [PMID] [PMCID]
- Muller KE, Tafe LJ, Gonzalez JL, West LA, Schned AR. Ovarian strumal carcinoid producing peptide YY associated with severe constipation: a case report and review of the literature. Int J Gynecol Pathol. 2015;34(1):30-5. [PMID] [DOI:10.1097/PGP.0000000000000117]
- Kaiho-Sakuma M, Toyoshima M, Watanabe M, Toki A, Kameda S, Minato T, et al. Aggressive neuroendocrine tumor of the ovary with multiple metastases treated with everolimus: A case report. Gynecol Oncol Rep. 2018;23:20-3. [DOI:10.1016/j.gore.2018.01.002] [PMID] [PMCID]
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