Document Type : Original Research
Authors
- Azadeh Rakhshan 1
- Esmat Arvin 1
- Sam Alahyari 2
- Behrang Kazeminezhad 3
- Tahmineh Mollasharifi 3
- Alireza Bagheri 1
- Fereshte Aliakbari 1
- Seyed Jalil Hosseini 1
- Mohammad Soleimani 4
- Mahsa Ahadi 1
- Elena Jamali 3
- Afshin Moradi 3
- Zahra Sadeghzadeh 1
- Saleh Ghiasi 4
- Malihe Nasiri 5
- Farzad Allameh 1
1 Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Pathology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Urology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background & Objective: The Paris System for Reporting Urinary Cytology (TPS) is a new method for evaluating urinary cytology designed to reduce unreproducible reports. The aim of this study was to reclassify and compare urinary cytology reports with TPS criteria to determine the frequency of unreproducible reports compared to the previous system.
Methods: In this study, the laboratory electronic registration system analyzed patients' urine samples taken by voided or washing and brushing methods. The cytological evaluation was performed considering the previous system and TPS by a pathologist. The results of the two systems were compared, and the sensitivity and specificity of TPS were calculated.
Results: Urine samples were taken from 876 patients. The mean age of patients was 63.36 ± 12.62. Comparing the routine classification system and TPS, it was observed that the number of atypical reports in the TPS system decreased by 12%, and all of these cases were downgraded to the negative group in the new classification. The sensitivity and specificity of TPS were 29.4% and 95.1%, respectively, if suspected malignancy and positive reports for malignancy were considered. Finally, if positive reports for malignancy were selected, sensitivity and specificity changed to 11.8% and 100%, respectively.
Conclusion: Although the TPS system has low sensitivity for the diagnosis of urothelial malignancies, due to its high specificity, it is possible to consider and use this classification for screening patients.
Keywords
Main Subjects
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