Iranian Journal of Pathology

Rad51 Expression in Nasopharyngeal Carcinoma and Its Association with Tumor Reduction: A Preliminary Study in Indonesia

Document Type : Short Communication

Authors

Dian Cahyanti 1
Lisnawati Rachmadi 1
Vally Wulani 2
Marlinda Adham 3

1 Dept. of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia

2 Dept. of Radiology, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia

3 Dept. of Ear Nose Throat Head and Neck Surgery, Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia

Abstract
Background: Overexpression of Rad51 protein in many tumor cells has been proven to increase radioresistance and can be related to the resistance of chemosensitivity of tumor cells. This preliminary study was conducted to determine the relationship between the Rad51 expression level in nasopharyngeal carcinoma and the response of the treatment based on the measurement of the tumor reduction. Methods:Thirteen cases of the NPCs were analyzed. The expression levels of the Rad51 were examined from the pretreatment biopsies. Furthermore, tumor reductions were determined based on the change in sum longest diameter of the nasopharyngeal CT-scan before and after therapy. Results: The expression level of the Rad51 was associated with the reduction of tumor mass.       The P value was 0.049 and the correlation coefficient was 0.479. Conclusion:The tumor cells Rad51 expression levels may affect the tumor reduction of NPC after the therapy.

Keywords

Nasopharyngeal carcinoma
Rad51 expression
Tumor reduction

Subjects

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Iranian Journal of Pathology
Volume 11, Issue 2 - Serial Number 2
Spring 2016
Pages 155-160

  • Receive Date 13 January 2015
  • Revise Date 06 March 2015
  • Accept Date 10 July 2015

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