Document Type : Case Reports

Authors

Dept. of Pathology, SHKM, GMC, Nalhar, Mewat, Haryana, India

Abstract

Malignant mixed germ cell tumors,though rare overall, are the most common type of malignant ovarian neoplasms in young and adolescent girls. These tumors are rapidly growing and can metastasize. We report a case of 13-yr-old girl who presented at SHKM GMC, Nalhar, Mewat, Haryana, India in December 2013 with huge abdominal lump of a malignant mixed germ cell tumor comprising both immature teratoma and embryonal carcinoma. This report illustrates the aggressiveness of this tumor and emphasises the need of early diagnosis and treatment.

Highlights

How to cite this article:
Rana S, Kaur Gill M, Kalhan S, Satarkar RN, Sangwaiya A, Singh P. Immature Teratoma with Embryonal Carcinoma; a Rare Malignant Mixed Germ Cell Tumor in a 13-Year-Old Girl. Iran J Pathol 2016; 11(1): 66-70.

Keywords

  1. M Koshy, A Vijayanathan, V Vadiveloo. Malignant ovarian germ cell tumor: a rare combination. Biomed Imaging Interv J 2005;1(2):e10.
  2. Munemane A, Munemane M. Malignant mixed germ cell tumours of ovary. A Report of two cases. Int J Med Sci Public Health 2014 [cited October11, 2015];3(1): 105-107.
  3. Kurman RJ, Noris HJ. Malignant germ cell tumors of ovary. Human Pathol1977;8:551-64.
  4. Kwok KKM, Loke TKL, Hui JPK, Lai MHY, Chan JCH. Malignant mixed germ cell tumor of the ovary in a 10 year old girl. JHK CollRadiol 2008;11:92-5.
  5. Gershenson DM, Del Junco G, Copeland LJ. Mixed germ cell tumors of the ovary. ObstetGynecol 1984;64(2):200-6.
  6. Bhattacharyya NK, De A, Bera P, Mongal S, Chakraborty S, Bandopadhyay R. Ovarian tumors in pediatric age group- A clinicopathologic study of 10 years’ cases in West Bengal, India. Ind J Med PaedOncol 2010;31(2):54-7.
  7. Abu-Zaid A, Nazer A, AlOmar O, Azzam A, Al-Eid HS, Elhassan TA et al. Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. HematolOncol Stem Cell Ther 2014;7(1):41-3.
  8. Cicin I, Eralp Y, Saip P, Ayan I, Kebudi R, Iyibozkurt C. Malignant Ovarian germ cell tumors. Am J ClinOncol 2009;32:191-6.
  9. Kurman RJ, Norris HJ. Embryonal Carcinoma of the ovary. A clinicopathologic entity distinct from endodermal sinus tumor resembling embryonal carcinoma of adult testis. Cancer 1976;38(6):2420-33.
  10. Williams SD. Ovarian germ cell tumors: an update. SeminOncol 1998;25(3):407-13.
  11. Sekiya S, Seki K, Nagai Y. Rise of serum CA 125 in patients with pure ovarian yolk sac tumors. Int J GynaecolObstet 1997;58:323-4.
  12.  Zanetta G, Bonazzi C, Cantu M. Survival and reproductive function after treatment of a malignant germ cell ovarian tumors. J Clin Oncol 2001;19(4):1015-20.
  13. Haider M,  Sanjeev K, Shelly S, Assaad S, Ramesh B, David L et al.    Prognostic impact of Laterality in Malignant Ovarian Germ Cell Tumor. Int J Gynecol Can 2011;21(2):257-62.