Ardashir Talebi; Fatemeh Pooralborzi; Hamid Reza Ghasemi Basir; Ahmad Reza Okhovvat; Danial Moghaddas
Volume 2, Issue 3 , June 2007, , Pages 115-117
Abstract
Myoepitheliomas are benign tumors which account for less than 1% of all salivary gland tumors. In this article, we report the clinical, pathologic, and immunohistochemical features of plasmacytoid myoepithelioma of the hard palate in a 73-year-old man having a painless hard palate mass with progressive ...
Read More
Myoepitheliomas are benign tumors which account for less than 1% of all salivary gland tumors. In this article, we report the clinical, pathologic, and immunohistochemical features of plasmacytoid myoepithelioma of the hard palate in a 73-year-old man having a painless hard palate mass with progressive growth for one month who was admitted in Alzahra Hospital of Isfahan University of Medical Sciences. The patient underwent a complete surgical resection of the tumor. Light microscopy showed a nodule with sharp margins of large cells with plasmacytoid aspect presenting round eccentric nuclei and an abundant and homogenous eosinophilic cytoplasm arranged in sheets and groups separated by an abundant, loose, myxoid and hyalinized matrix. Immunohistochemistry was performed on formalin-fixed and paraffin-embedded tissue with a panel of immunohistochemical markers comprising cytokeratin (CK), vimentin, S100, actin and EMA. Tumor cells showed strong and diffuse positivity for S100 and also CK, vimentin, and actin, but confirming the myoepithelial origin of the tumor, EMA immunostaining was negative.
Mitra Mehrazma1; Soraya Salehi; Shokrollah Yousefi; Selaheddin Delshad; Ahmad Jalilvand; Alireza Hasanpour
Volume 1, Issue 4 , September 2006, , Pages 155-160
Abstract
Background and Objective: Mediastinal masses in children are a heterogenous group of asymptomatic potentially life-threatening congenital, infectious, or neoplastic lesions that present complex diagnostic and therapeutic dilemmas. Materials and Methods: The clinical and laboratory features of 65 patients ...
Read More
Background and Objective: Mediastinal masses in children are a heterogenous group of asymptomatic potentially life-threatening congenital, infectious, or neoplastic lesions that present complex diagnostic and therapeutic dilemmas. Materials and Methods: The clinical and laboratory features of 65 patients who had open biopsies in Ali-Asghar hospital over 11 years were reviewed. Results: Seventy-two percent of cases were male and 28% were female. The age varied between 2.5 months and 19 years. Eighty-four percent of lesions were malignant and 16% were benign. Neurogenic tumors were the most common (36.9%). In order of frequency the following lesions were the most common neuroblastoma (mostly in posterior mediastinum), Hodgkin’s and non-Hodgkin’s lymphoma (mostly in middle mediastinum), and malignant small round cell tumor (mostly in chest wall). Most patients were presented by fever (21.5%), dyspnea (20%) and cough (12%), especially in Hodgkin’s and non-Hodgkin’s lymphoma. Lymphadenopathy (29.2%) and hepatosplenomegaly (13.8%) were the most frequent clinical signs. Laboratory examination revealed anemia (29%), leukocytosis (35%), and high sedimentation rate (21.5%). Conclusion: The clinical presentation and laboratory findings of mediastinal and chest wall masses are often non-specific and are variable, but according to their clinical data (i.e. age) and location, only few important diagnoses should be considered.
