Atoosa Gharib; Azadeh Rakhshan; Farzaneh Jadali
Volume 3, Issue 3 , June 2008, , Pages 168-169
Abstract
Gastrointestinal aspergillosis most often occurs in the setting of disseminated infection from a primary pulmonary site and primary gastrointestinal aspergillosis is an unusual presentation. We report a 7 year old female child with aplastic anemia, who was under treatment but experienced periods ...
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Gastrointestinal aspergillosis most often occurs in the setting of disseminated infection from a primary pulmonary site and primary gastrointestinal aspergillosis is an unusual presentation. We report a 7 year old female child with aplastic anemia, who was under treatment but experienced periods of neutropenia. She had no evidence of respiratory aspergillosis before the onset of abdominal symptoms including severe abdominal pain and rectorrhagia.The patient died of septic shock two weeks after emergency surgery for rectal bleeding. Although a rare condition, primary gastrointestinal aspergillosis should be considered in differential diagnosis of gastrointestinal symptoms in neutropenic patients.
Farzaneh Jadali; Abdollah Karimi; Shahnaz Armin; Atoussa Gharib; Fatemeh Fallah; Mohammad Sharifian; Elham Mazaheri-tehrani
Volume 2, Issue 3 , June 2007, , Pages 89-93
Abstract
Background and Objective: BCG vaccination is used in many countries with a high prevalence of TB to prevent childhood tuberculosis meningitis and miliary disease. Local and systemic sideeffects are associated with BCG vaccine. The most critical reaction is disseminated BCG infection which occurs in mostly ...
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Background and Objective: BCG vaccination is used in many countries with a high prevalence of TB to prevent childhood tuberculosis meningitis and miliary disease. Local and systemic sideeffects are associated with BCG vaccine. The most critical reaction is disseminated BCG infection which occurs in mostly immunodeficient patients. Materials and Methods: We performed 4 autopsies during 2001-2003 which were suspected for BCGosis clinically and histologically by presence of granulomatous foci in several organs with acid fast bacilli. The mycobacteria were identified by PCR. Their DNA was extracted from the tissue blocks, identified with primers which were designed to detect the RD1 deletion. Results: We found BCG genome by PCR in 3 out of 4 patients. These patients had acid fast bacilli in special staining. Conclusion: Since BCGosis is a fatal and uncommon disease, occurring after vaccination with numerous complications, its diagnosis is of paramount importance and should be considered in the appropriate clinical setting.
