Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Review Article Biochemistry
Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review

Morteza Hassandokht Mashhadi; Fahimeh Taheri; Sadaf Irani; Arshiya Mesbah Mousavi; Ali Mehri; Hossein Javid

Volume 19, Issue 1 , January 2024, Pages 1-9

https://doi.org/10.30699/ijp.2023.1999459.3093

Abstract
  The effectiveness of immunotherapy for most cancer patients remains low, with approximately 10–30% of those treated surviving. Thus, much effort is being put into finding new ways to improve immune checkpoint therapy. Our review concludes that the inhibition of proprotein convertase subtilisin/Kexin ...  Read More

Original Research Gynecologic Pathology
FABP4, GINS2 and CBX7 Expression in Cancer Cervix Tissues: Clinical, Pathological and Prognostic Implications

Mariem A Elfeky; Rema H Faraj Saad; Mohamed Ali Alabiad; Mohammed Alorini; Rehab Hemeda; Ramadan M Ali; Loay M Gertallah; Mohamed Negm; Ahmed Mahmoud Abdou; Ahmed Baker A Alshaikh; Ahmed Elmaasrawy

Volume 19, Issue 1 , January 2024, Pages 10-21

https://doi.org/10.30699/ijp.2023.1971325.2994

Abstract
  Background: Cervical cancer spreads to the pelvic lymph nodes, leading to a high incidence of cancer recurrence and unfavorable survival rates. Therefore, there is an urgent need to detect new predictive biomarkers for the early assessment of pelvic lymph node status in patients with cervical cancer. ...  Read More

Original Research GI, Liver & Pancreas Pathology
Immunohistochemical Expression of Programmed Death Ligand- 1 (PD-L1) in Colorectal Carcinoma; A Cross-sectional Study

Shruti Tadachina; Sheela Devi Shivalingaiah; Mahesh Shetty

Volume 19, Issue 1 , January 2024, Pages 22-30

https://doi.org/10.30699/ijp.2023.1988660.3054

Abstract
  Background & Objective: Colorectal carcinoma (CRC) is one of the most common cancers worldwide. The interaction of programmed cell death receptor 1 (PD-1) and programmed death ligand 1 (PD-L1) plays an important role by inhibiting the immune mechanism by which cancer cells escape antitumor immunity. ...  Read More

Original Research Breast Pathology
Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer

Negin Parsamanesh; Shabnam Shahidi; Parvin Ansari Shayesteh; Mahsa Alami

Volume 19, Issue 1 , January 2024, Pages 31-49

https://doi.org/10.30699/ijp.2023.1995769.3077

Abstract
  Breast cancer is one of the common malignant tumors worldwide accounting for 15% of all cancer-related deaths. Since a timely diagnosis of BC is essential for optimal treatment and also increasing the survival rate of patients. Today, various financial support is applied to find the best biomarkers. ...  Read More

Original Research Uropathology
Study of Expression of P16 in Premalignant and Malignant Lesions of Penis and Their Significance

Manish Shetty; Deepa Sowkur Anandarama Adiga; Chaithra GV

Volume 19, Issue 1 , January 2024, Pages 50-58

https://doi.org/10.30699/ijp.2023.1998898.3092

Abstract
  Background & Objective: Penile squamous cell carcinoma (SCC) is an extremely rare malignancy. It is usually caused by chronic human papillomavirus (HPV) 16 and HPV 18 infections. This study was conducted to investigate the immunohistochemical overexpression of p16, a surrogate marker for HPV, and ...  Read More

Original Research GI, Liver & Pancreas Pathology
Histopathologic and Prognostic Significance of Tumor Budding in Colorectal Adenocarcinoma: A Retrospective Cohort Study Conducted in Shiraz, Iran

Mohammad Hossein Anbardar; Nadia Rahimizadeh

Volume 19, Issue 1 , January 2024, Pages 59-66

https://doi.org/10.30699/ijp.2023.1999329.3090

Abstract
  Background & Objective: Colorectal cancer is the second reason for cancer-associated death. The prognosis of the malignancy is defined by TNM scoring. However, tumor grading, lymphovascular invasion, perineural invasion, and tumor buddings may affect its prognosis. This study aimed to assess the ...  Read More

Original Research Breast Pathology
α-Smooth Muscle Actin as Predictors of Early Recurrence in Early-Stage Ductal Type Breast Cancer After Mastectomy and Chemotherapy

Andreas Andrianto; I Ketut Sudiana; Desak GA Suprabawati

Volume 19, Issue 1 , January 2024, Pages 67-74

https://doi.org/10.30699/ijp.2023.2004468.3126

Abstract
  Background & Objective: Breast cancer recurrence after surgery was a sign that the progress of the disease was continuing. Early detection of breast cancer patients who are at risk requires  development of a marker. Alfa smooth muscle actin (α-SMA) plays a role in the local recurrence ...  Read More

Original Research Diagnostic Pathology
Comparative Study of Ki-67 Labeling Index Quantification by Eye-rolling, Manual Count, and Digital Image Analysis; An Approach with Caution

Aminder Singh; Vikram Narang; Ankita Soni; Kajal Angural; Saveena Jindal; Bhavna Garg; Harpreet Kaur

Volume 19, Issue 1 , January 2024, Pages 75-80

https://doi.org/10.30699/ijp.2023.2008346.3150

Abstract
  Background & Objective: An accurate Ki-67 labeling index assessment is critical for managing a few tumors, like breast carcinomas and neuroendocrine tumors. We aimed to determine the degree of agreement between digital image analysis (DIA) & eye-rolling assessment (EE) and DIA & manual count ...  Read More

Original Research Uropathology
Do Fibroblast Growth Factor Receptor (FGFR) 2 and 3 Proteins Play a Role in the Prognosis of Invasive Urothelial Bladder Carcinoma?

Shereen Fathy Mahmoud; Nanis Shawky Holah; Alshimaa mahmoud Alhanafy; Marwa Mohammed Serag El-Edien

Volume 19, Issue 1 , January 2024, Pages 81-88

https://doi.org/10.30699/ijp.2023.2012115.3180

Abstract
  Background & Objective: Bladder carcinoma ranks second in prevalence among males in Egypt. As a family of tyrosine kinases, fibroblast growth factor receptor (FGFR) dysregulation has been linked to some malignancies in humans. The aim of this study is to analyze the clinicopathological data of patients ...  Read More

Original Research GI, Liver & Pancreas Pathology
Role of CTLA4 and pSTAT3 Immunostaining in Colorectal Carcinoma Prognosis and Treatment

Dina Mohamed Allam; Hend Ahmed Kasem; Amira Hegazy; Shereen Fathy Mahmoud

Volume 19, Issue 1 , January 2024, Pages 89-102

https://doi.org/10.30699/ijp.2024.2009619.3158

Abstract
  Background & Objective: Colorectal carcinoma (CRC) is the third leading cause of cancer-caused death worldwide and constitutes about 6.48% of all malignancies in Egypt. Studying the molecular profile of CRC is essential for developing targeted therapies. STAT3 and CTLA4 expression are among the molecular ...  Read More

Short Communication Breast Pathology
Effective Ki-67 Reduction by Short-Term Administration of Letrozole Before Surgery in (Hormone-Positive) Breast Cancer

Bita Eslami; Sadaf Alipour; Farzaneh Golfam; Behnaz Jahanbin; Ramesh Omranipour

Volume 19, Issue 1 , January 2024, Pages 103-106

https://doi.org/10.30699/ijp.2023.2002772.3118

Abstract
  Background & Objective: Antigen Ki-67 (histone-based nuclear protein) is a static marker of tumor cell proliferation and growth and is commonly measured to indicate the effect of treatment in breast cancer patients. This single-arm trial study aimed to evaluate the effect of short-term endocrine ...  Read More

Case Reports Head and Neck Pathology
Sclerosing Microcystic Adenocarcinoma of the Base of Tongue with Signet Ring-Like Cell Component: A Rare Case

Parisa Mokhles; Alireza Sadeghipour; Maryam Kadivar; Nasrin Shayanfar; Zahra Keshtpour Amlashi; Pegah Alizadeh Pahlavan; Ashkan Shafiei

Volume 19, Issue 1 , January 2024, Pages 107-113

https://doi.org/10.30699/ijp.2023.1989943.3068

Abstract
   Sclerosing microcystic adenocarcinoma (SMA) is an uncommon neoplasm of the oral cavity, with only 14 reported cases documented in the literature.We present a case of SMA in a 65-year-old woman with a history of high-grade lymphoma who developed clear cell changes in the deep muscular layer of the ...  Read More

Case Reports GI, Liver & Pancreas Pathology
Primary Malignant Melanoma of the Small Intestine Presenting with Peritonitis: A Case Report

Alireza Khooei; Sahar Seifnia; Amin Dalili; Hossein Bavandi; Saeid Dehghan Nezhad; Motahare Ebrahimnejad

Volume 19, Issue 1 , January 2024, Pages 114-117

https://doi.org/10.30699/ijp.2023.1996329.3100

Abstract
  Malignant melanoma of the small intestine is mostly a metastatic tumor of other primary lesions, especially of skin origin. Primary malignant melanoma of the small intestine is very uncommon. The clinical presentation is usually nonspecific, thus leading to late diagnosis.We report a 42-year-old man ...  Read More

Case Reports Breast Pathology
Primary Undifferentiated Pleomorphic Sarcoma of the Breast; a Case Report with Literature Review of Similar Cases

Amirhossein Jafarian; Mohaddeseh Shahraki; Samaneh Sajjadi; Behrooz Daneshmand

Volume 19, Issue 1 , January 2024, Pages 118-125

https://doi.org/10.30699/ijp.2023.2006411.3139

Abstract
  Background: Breast sarcoma is a rare, but aggressive tumor. There are few case reports in the literature and several aspects of this disease are still not completely comprehended. Therefore, reporting new cases can help to enrich the literature.Case Presentation: We report a case with a breast mass and ...  Read More

Case Reports Pulmonary Pathology
Histopathological Examination of Lung Necropsy of 11 Patients Who Died Due to COVID-19: A Case Series

Bahram Nikkhoo; Karim Naseri; Ramyar Rahimi Darehbagh; Mehrdad Habiby; Bahar Moasses-Ghafari

Volume 19, Issue 1 , January 2024, Pages 126-131

https://doi.org/10.30699/ijp.2023.2008773.3153

Abstract
  BackgroundCovid-19 in known to present with acute respiratory distress syndrome pathological manifestations. Studies have shown that patients with Covid-19 can develope diffuse alveolar damage, acute bronchopneumonia, necrotic bronchiolitis, and viral pneumonia.Case PresentationIn this study, we investigate ...  Read More

Case Reports Molecular Pathology
Pediatric Inflammatory Myofibroblastic Tumor of Rectosigmoid Junction: A Case Report and Review of the Literature

Mohammad Vaseie; Mahsa Soti Khiabani; Maryam Monajemzadeh; Hojatollah Raji; Fatemeh Zamani; Neda Pak

Volume 19, Issue 1 , January 2024, Pages 132-136

https://doi.org/10.30699/ijp.2024.2003653.3122

Abstract
  The occurrence of rectosigmoid junction inflammatory myofibroblastic tumor IMT is uncommon in children. This is a rare form of mesenchymal tumor, belonging to the category of soft tissue tumors, and can be found at any anatomical site from the central nervous system to the gastrointestinal tract.Our ...  Read More