Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)

Spectrum of Malignant Transformation in Marjolins Ulcer: Our Experience of This Rare Phenomenon

Mitra Mustaphi Ruplekha; Gon Sonia; Bhattacharyya Roop Narayan

Volume 9, Issue 1 , January 2014, , Pages 1-8

    Background & Objective: Chronic non healing ulcers or scar undergoing malignant transformation is a rare phenomenon with an estimated incidence of 2%. Though, numerous predisposing factors have been identified, still it is rarely diagnosed and commonly mistaken for a benign condition. The ...  Read More

Comparison of Prostatic Tissue Processed by Microwave and Conventional Technique Using Morphometry

Promil Jain; Sanjay Kumar; Brij Bala Arora; Sneh Singh; Sonia Chabbra; Rajeev Sen

Volume 10, Issue 1 , January 2015, , Pages 1-8


   Background and Objectives:Rapid processing of histopathological specimens and decreased turnaround time is important to fulfill the needs of clinicians treating sick patients, so the present study was conducted to compare the time taken and quality of sections in processing of prostatic tissue ...  Read More

Parasitemia and Hematological Alterations in Malaria: A Study from the Highly Affected Zones

Sethi Bhawna; Arora Bharti; Kumar Yogesh; Aggarwal Reena

Volume 8, Issue 1 , January 2013, , Pages 1-8

  Background& Objectives: Inspite of intensive worldwide efforts to reduce its transmission, malaria remains the most serious and widespread protozoal infection of humans. It is a protozoan disease transmitted by the bite of infected female anopheles mosquito. Malaria has long featured prominently ...  Read More

Molecular-Friendly Histopathology

Mehdi Nassiri; Mehrdad Nadji

Volume 1, Issue 1 , January 2006, , Pages 1-6

  The rapidly expanding fields of pharmacogenomics and pharmacodiagnostics have presented the pathology laboratories with many challenges and opportunities. As custodians of patient tissues, these laboratories are in the logical position to perform biomolecular testing for proper management of patients. ...  Read More

A Practical Guide to Differential Diagnosis of Small B Cell Lymphomas

Mehdi Nassiri

Volume 2, Issue 1 , January 2007, , Pages 1-6

  Correct diagnosis and classification of lymphoid neoplasms depends on the integration of morphologic, immunophenotypic and molecular genetic features. The mature small B cell lymphomas despite their overlapping histomorphologies, have different clinical behavior and treatment. In this review, differential ...  Read More

Association between Helicobacter pylori Infection and Atherosclerotic Coronary Artery Disease

Nehzat Akiash; Younes Nozari; Naser EbrahimiDaryani; Alireza Abdollahi

Volume 4, Issue 1 , January 2009, , Pages 1-4

    Background and Objectives: Cardiovascular disease is the most common cause of death in developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis, ...  Read More

Volumetric Study Of Dentate Gyrus And CA3 Region In Hippocampus Of Streptozotocin-Induced Diabetic Rats: Effect Of Insulin And Ascorbic Acid

Shahriar Ahmadpour; Hossein Haghir; Yousef Sadeghi

Volume 3, Issue 1 , January 2008, , Pages 1-4

    Background and Objectives: Hippocampal volume reduction has been reported in diabetes mellitus type 1. It is believed that hyperglycemia and oxidative stress mediate neuropathological changes in hippocampal neurons. In this study we aimed to study the effect of insulin and an antioxidant like ...  Read More

Thyroid Papillary Microcarcinoma: Etiology, Clinical Manifestations, Diagnosis, Follow-up, Histopathology and Prognosis

Shiva Dideban; Alireza Abdollahi; Alipasha Meysamie; Shokouh Sedghi; Mona Shahriari

Volume 11, Issue 1 , January 2016, , Pages 1-19

  Background: Thyroid carcinoma is the most common malignancy of the endocrine system. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, accounting for 70–90% of well-differentiated thyroid malignancies. Thyroid papillary microcarcinoma is a subtype of papillary carcinoma ...  Read More

Malignant Colorectal Polyps; Pathological Consideration (A review)

Bita Geramizadeh; Mahsa Marzban; David Owen

Volume 12, Issue 1 , January 2017, , Pages 1-8


  Background: Routine screening colonoscopy is on the rise and pathologists have to deal with the ever larger numbers of excised colonic polyps. It is very important to optimize the patients’ individual treatment and further surveillance. Pathologists play a critical role in management, as most of ...  Read More

Prevalence of Clinically Isolated Metallo-beta-lactamase-producing Pseudomonas aeruginosa, Coding Genes, and Possible Risk Factors in Iran

Abdolmajid Ghasemian; Kobra Salimian Rizi; Hassan Rajabi Vardanjani; Farshad Nojoomi

Volume 13, Issue 1 , January 2018, , Pages 1-9


  Background & Objective: The spread of carbapenem-resistant Pseudomonas aeruginosa is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria. The current study aimed at determining the prevalence of MBL-producing P. aeruginosa in Iran. Methods: ...  Read More

Molecular Pathology
Epidermal Growth Factor Receptor (EGFR) Gene Mutation Analysis in Adenocarcinoma of Lung, the First Report from Iran

Sahand Mohammadzadeh; Zahra Jowkar; Mitra Mirzaee; Bita Geramizadeh

Volume 14, Issue 1 , January 2019, , Pages 1-7


  Background and Objective: Epidermal growth factor receptor (EGFR) gene mutation, especially in exons 18 to 21, is an important predictor of the response rate of lung adenocarcinoma to tyrosine kinase inhibitors. There are variable reports from Asian and European countries, as well as North America, about ...  Read More

Characterization of Immunophenotypic Aberrancies in Adult and Childhood Acute Lymphoblastic Leukemia: Lessons from Regional Variation

Mitra Rezaei; Sandra Refoua; Najme Esfandiari; Masoud Shamaei

Volume 15, Issue 1 , January 2020, , Pages 1-7


  Background & Objective:Although the antigen expression patterns of acute lymphoblastic leukemia (ALL) are well known, this study attempted to evaluate commonly used immune markers for immunophenotyping of acute leukemia to set the minimum of necessary diagnostic panels by flow cytometry.Methods:This ...  Read More

Molecular Pathology
Pre-analytical Practices in the Molecular Diagnostic Tests, A Concise Review

Maryam Sotoudeh Anvari; Atoosa Gharib; Maryam Abolhasani; Aileen Azari-Yaam; Farzaneh Hossieni Gharalari; Moeinadin Safavi; Ali Zare-Mirzaie; Mohammad Vasei

Volume 16, Issue 1 , January 2021, , Pages 1-19


  Molecular assays for detection of nucleic acids in biologic specimens are valuable diagnostic tools supporting clinical diagnoses and therapeutic decisions. Pre-analytical errors, which occur before or during processing of nucleic acid extraction, contribute a significant role in common errors which ...  Read More

Head and Neck Pathology
Salivary Gland Tumors in Iran: A Systematic Review of 2870 Cases Based on the New WHO Classification

Sahar Assar; Sepideh Assar; Heidar-Ali Mardanifard; Zohreh Jaafari-Ashkavandi

Volume 18, Issue 1 , January 2023, , Pages 1-11


  Background & Objective: There is no consensus on the prevalence of salivary gland tumors (SGTs) in Iran. Thus, we systematically reviewed the literature about the prevalence of SGTs in Iran and applied the last world health organization (WHO) classification.Methods: The systematic literature search ...  Read More

Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review

Morteza Hassandokht Mashhadi; Fahimeh Taheri; Sadaf Irani; Arshiya Mesbah Mousavi; Ali Mehri; Hossein Javid

Volume 19, Issue 1 , January 2024, , Pages 1-9


  The effectiveness of immunotherapy for most cancer patients remains low, with approximately 10–30% of those treated surviving. Thus, much effort is being put into finding new ways to improve immune checkpoint therapy. Our review concludes that the inhibition of proprotein convertase subtilisin/Kexin ...  Read More


Moslem Bahadori; Forouzan Mohammadi

Volume 1, Issue 2 , April 2006, , Pages 41-48

  Since its original conception in 1959, by Nobel physicist Richard P Feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. One of the most promising applications of nanotechnology is in the context of medicine. ...  Read More

Deprenyl Can Mediate Neuronal Protection Rather than Neuronal Rescue

Marjan Heshmati; Hesam Amini

Volume 2, Issue 2 , April 2007, , Pages 45-48

  Background and Objective: Deprenyl is a drug for the treatment of Parkinson’s disease, where the dopaminergic neurons are the target of this drug. Several reports also documented that deprenyl has an effect on the sensory and motor neurons. There are some reports about the mode of action of deprenyl ...  Read More

Tumorogensis : The Dual Role of Telomerase

Joharia azhar

Volume 4, Issue 2 , April 2009, , Pages 51-58

    Carcinogenesis is a multistep process characterized by the gradual accumulation of genetic changes that ultimately lead to cancer. These genetic mutations can impart limitless replicative potential to the cancer cells making them immortal. Telomeres are repeat nucleotide sequence TTAGGG that ...  Read More

Association Of Maternal Hypothyroidism With Pre-eclampsia

Nahid Mostaghel; Elham Tavanayanfar; Elham Neisani Samani

Volume 3, Issue 2 , March 2008, , Pages 51-54

    Background and Objective: Hypertensive disorders complicating pregnancy are common and from one of the deadly triad, along with hemorrhage and infection that contribute greatly to prenatal and maternal morbidity and mortality in the developing countries. This study was designed to investigate ...  Read More

Prediction of Clinical Course and Biologic Behavior of the Bone Giant Cell Tumor Using Bax and bcl-2 Markers

Reza Ataei; Alireza Khooei; Mohammad Gharedaghi

Volume 5, Issue 2 , March 2010, , Pages 53-59

    Background and Objectives: Giant cell Tumor of bone (GCT) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. Histological features of the tumor often could not predict its future ...  Read More

Diagnostic Pathology
Knowledge of Laboratory Medicine in Medical Students: Is It Sufficient?

Hiva Saffar; Maryam Saatchi; Anahita Sadeghi; Fahimeh Asadi Amoli; Seyed Mohammad Tavangar; Farzaneh Shirani; Ali Aliasgari

Volume 15, Issue 2 , April 2020, , Pages 61-65


  Background & Objective: Appropriate use of laboratory testing is essential for achieving safe and effective care to patient. Insufficient knowledge could lead to poor case management and increase the health care costs. It is believed that education on laboratory testing for undergraduate medical ...  Read More

Muscle Biopsy

Elahe Keyhani

Volume 7, Issue 2 , April 2012, , Pages 63-69

  Muscle biopsy has been used for a long time for diagnosis of muscular, nerurogenic and systemic disorders with muscle involvement, because only very few of these disorders show sufficient specific clinical features for definite diagnosis. Since the presence of difficulties in the screening of numerous ...  Read More