TY - JOUR ID - 8580 TI - Lipid Profile in Subjects with Helicobacter pyloriInfection JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Aarabi, Mohamad Hosein AU - Alvani, Shokofeh AU - Ehteram, Hassan AD - Dept. of Clinical Biochemistry, Kashan University of Medical Sciences, Kashan, Iran AD - Dept. of Physiology and Pharmacology, Kashan University of Medical Sciences, Kashan, Iran AD - Dept. of Pathology, Kashan University of Medical Sciences, Kashan , Iran Y1 - 2010 PY - 2010 VL - 5 IS - 4 SP - 199 EP - 203 KW - Helicobacter pylori KW - Lipid profile KW - Coronary Heart Disease KW - Atherosclerosis KW - serum lipid levels DO - N2 -   Background and Objectives:  Helicobacter pylori cause a chronic gastric infection, and may cause extra gastrointestinal disease. The association between H. pylori infection and serum lipid profiles is still controversial. The aim of this study was to investigate any possible relationship between H. pylori infection and lipid levels. Materials and Methods: The subjects were 400 volunteer referring to medical centers of Kashan, Iran between December 2005 and March 2006. Helicobacter pylori infection status was determined by assaying serum anti-H. pylori immunoglobulin G antibody. Total cholesterol, HDL-cholesterol, triglyceride concentrations were measured by routine enzymatic methods. The data for H. pylori-seropositive and –seronegative individuals were compared. Results: Three hundred nineteen subjects (79.8 percent) were H. pylori-seropositive. The serum triglyceride concentration and total cholesterol/HDL-cholesterol ratio were significantly higher in H. pylori-seropositive than H. pylori–seronegative individuals (162.03 vs. 143.88 mg/dl, P<0.05 and 4.27 versus 3.91, P<0.05 respectively). Conclusion: The findings confirm the existence of a moderate association between H. pylori infection and lipid modulation. It is also possible that H. pylori infection promotes atherosclerosis by acting through changes in lipid profile.   UR - https://ijp.iranpath.org/article_8580.html L1 - https://ijp.iranpath.org/article_8580_2960897fd6a0ce2f32e60469142a3038.pdf ER -