TY - JOUR ID - 39854 TI - The Survival of Patients with t(15;17)(q22;q12) Positive Acute Promyelocytic Leukemia: A Study in North-East of Iran JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Ayatollahi, Hossein AU - Bazi, Ali AU - Sadeghian, Mohammad Hadi AU - Fani, Ali AU - Siyadat, Payam AU - Sheikhi, Maryam AU - Sargazi-aval, Omolbanin AD - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AD - Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran AD - Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran AD - Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2020 PY - 2020 VL - 15 IS - 3 SP - 175 EP - 181 KW - Acute myeloid leukemia, Acute promyelocytic leukemia, Blood cancer, Survival, t(15 KW - 17)(q22 KW - q12) DO - 10.30699/ijp.2020.101417.2007 N2 - Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML).  Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran. Methods:  Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was obtained from archived medical records. Statistical analysis was performed by SPSS 18 software using log-ranked test and Kaplan Maier survival analysis. Results: Females and males comprised 49% and 51%, respectively. The mean age at diagnosis was 34.3 ± 14.1 years old. During the study period, 17 demises occurred in males, while this number was 7 in females. The mean survival of patients (month) was 23.22 ± 3.57 (95% CI: 16.21 ± 30.2). The five-year survival rate obtained 30%. Regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count <10±/l (48%), and platelet count >140 ± /l (100%). Conclusion: Younger age, lower WBC count and higher platelet count were significantly associated with longer survival in AML patients with t(15;17)(q22; q12). UR - https://ijp.iranpath.org/article_39854.html L1 - https://ijp.iranpath.org/article_39854_46fc0465453397d920595d40e90c7b80.pdf ER -