TY - JOUR ID - 36628 TI - Absence of Human Papillomavirus in Benign and Malignant Breast Tissue JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Kazemi Aghdam, Maryam AU - Nadji, Seyed Alireza AU - Alvandimanesh, Azadeh AU - Khoddami, Maliheh AU - Khademi, Yassaman AD - Pediatric Pathology Research Center, Research Institute for Children’s Heath, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Virology Research Center (VRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Department of Pathology, Shafa Hospital, Qazvin University of Medical Sciences, Qazvin, Iran AD - Department of Pathology, Pathobiology Laboratory Center, Tehran, Iran Y1 - 2019 PY - 2019 VL - 14 IS - 4 SP - 279 EP - 283 KW - Breast KW - Benign KW - Malignant KW - Human papillomavirus KW - Polymerase chain reaction DO - 10.30699/ijp.2019.89684.1847 N2 - Background & Objective: Malignant breast tumors, which are one of the most important deadly cancers in women, like many other cancers, are proposed to be related to viruses etiologically. Proper management of breast carcinoma necessitates an identification of the etiological factors. Human Papilomavirus is considered to have an etiological role in breast carcinoma. We carried out this study to find out if Human Papilomavirus-DNA is present in the malignant and benign breast tissue in our patients. Methods: Seventy five paraffin-embedded breast cancer tissues and 75 normal breast tissues and benign breast lesions were examined in this study (case-control) to look for Human Papilomavirus-DNA employing Nested Polymerase Chain reaction. The tissues were examined over a period of ten years in the pathology department of the Pathobiology Laboratory Center of Tehran. Result: No Human Papilomavirus-DNA was found in any of the malignant or control group specimens. Conclusion: Our results showed no evidence of Human Papilomavirus in cancerous and benign tissues, which is consistent with some other studies in English medical literature. More investigations using more specimens from different parts of the country are required to confirm the presence or absence of any connection between Human Papilomavirus and development of breast carcinoma in Iran. UR - https://ijp.iranpath.org/article_36628.html L1 - https://ijp.iranpath.org/article_36628_515dbcf13517a02ac4f88e72eabf8522.pdf ER -