TY - JOUR ID - 32430 TI - Metachronous Malignant Fibrous Histiocytoma- A Rare Case Report JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Rawal, Gireesha AU - Zaheer, Sufian AU - Yadav, Amit AU - Dhawan, Indrani AD - Dept. of Pathology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India Y1 - 2018 PY - 2018 VL - 13 IS - 4 SP - 474 EP - 478 KW - Metachronous KW - Malignant fibrous histiocytoma DO - N2 - Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. Distant metastases are developed in 30–40% of patients with MFH, with the most common site being the lung. However, metachronous MFH has not been reported previously in literature. This report describes a case of a 30-year-old man, who had two metachronous thigh tumors, both of which were confirmed to be MFH on histopathology and immunohistochemistry evaluations. A contemporary multidisciplinary approach to therapy including surgery, radiation and chemotherapy was advocated. Two primary sites of MFH raised the possibility of a genetic abnormality that could predispose such a patient to develop multiple primary sites of the same tumor. UR - https://ijp.iranpath.org/article_32430.html L1 - https://ijp.iranpath.org/article_32430_b8ed346947fbdd655750f3a65aa263fc.pdf ER -