TY - JOUR ID - 32116 TI - Non-scarring Alopecias in Iranian Patients: A Histopathological Study With Hair Counts JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Sari Aslani, Fatemeh AU - Heidari Esfahani, Mina AU - Sepaskhah, Mozhdeh AD - Dept. of Pathology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Dept. of Pathology, Valiasr Hospital, Fasa University of Medical Sciences, Fasa, Iran AD - Dept. of Dermatology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2018 PY - 2018 VL - 13 IS - 3 SP - 317 EP - 324 KW - Scalp Biopsy KW - Non-scarring Alopecia KW - Androgenetic Alopecia KW - Alopecia Areata KW - Telogen Effluvium DO - N2 - Background and Objective: Non-scarring alopecia is a challenge in the diagnosis and treatment, rarely studied in Asian countries. The current study aimed at evaluating histopathological features including hair count of different subtypes of non-scarring alopecia in Iranian patients.Methods: The current study was conducted on 114 cases diagnosed with non-scarring alopecia in Molecular Dermatology Research Center and Pathology Department of Shiraz University of Medical Sciences, Shiraz, Iran. Cases with two 4-mm scalp punch biopsies were selected. Patients’ clinical data were compared with histological findings.Results: Androgenetic alopecia (AGA) was the most common subtype Followed by alopecia areata (AA) and combined AGA/telogen effluvium (TE). Perifollicular inflammation was observed in 21% of AGA with a significant difference in males and females (66.7% vs. 33.3%; P-value <0.05). Clinical and histopathologic diagnoses were correlated in 55% of cases. Maximum correlation was observed in combined AGA and chronic TE (88%). For vertical sections, the diagnostic rate was 33.6%, while 88% for transverse sections.Conclusion: Transverse together with vertical sectioning provides most of the information in non-scarring alopecias, while transverse sectioning is enough to diagnose the majority of non-scarring alopecias. Perifollicular inflammation was observed in a significant number of cases with AGA, more common in males. It is suggested to report such cases as possibly curable. UR - https://ijp.iranpath.org/article_32116.html L1 - https://ijp.iranpath.org/article_32116_242f8d3ebe27e4c1434b3d06fa1cef90.pdf ER -