TY - JOUR ID - 31712 TI - The Correlation Between Serum Vitamin D Level and Total Antioxidant Capacity in diabetic and Non-diabetic Subjects in Iran JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Zare-Mirzaie, Ali AU - Kazeminezhad, Behrang AU - Akbari Ghouchani, Mona AD - Dept of Pathology, Iran University of Medical Sciences, Rassool Akram Hospital, Tehran, Iran AD - Dept of Pathology , Shahid Beheshti University of Medical Science, Shahid Modarres Hospital,Tehran ,Iran Y1 - 2018 PY - 2018 VL - 13 IS - 2 SP - 212 EP - 219 KW - Total Antioxidant Capacity KW - Diabetes Mellitus KW - Oxidative stress KW - Vitamin D DO - 10.30699/ijp.13.2.212 N2 - Background& Objective:  Increase in intra- and extracellular glucose levels can cause oxidative stress, and the prolonged imbalance between prooxidants and antioxidantscan lead to cell damage and the associated complications in patients with diabetes. Vitamin D acts as a strong antioxidant in the body and several studies emphasized on its important role to prevent oxidative stress in prediabetic and diabetic subjects. The current study aimed at determining and comparing the total antioxidant capacity (TAC) in individuals with hemoglobin A1c (HbA1c) below and above 6.5%, and its correlation with vitamin D levels. Methods: The current cross sectional study was conducted on a total of 107 patients with diabetes (HbA1c >6.5%) and 107 non-diabetic subjects (HbA1c <6.5%) referred to Rassool Akram Hospital, Tehran, Iran from 2015 to 2016, as the sample population. The two groups were compared regarding their TAC and vitamin D serum levels and the association between vitamin D concentration and TAC was evaluated.  Results: Age and body mass index (BMI)were significantly higher in patients with diabetes, compared with the serum levels of vitamin D and TAC (P P=0.003). In multivariate regression model, the duration of diabetes was also significantly associated with TAC level (beta coefficient=-0.82, P <0.001).  Conclusion: The low serum levels of TAC and vitamin D in patients with diabetes could be indicative of oxidative stress in the presence of high blood glucose levels. Supplementation of vitamin D in patients with diabetes might be effective to control the negative impacts of the disease and decrease cells’ exposure to oxidative environment in prediabetes. UR - https://ijp.iranpath.org/article_31712.html L1 - https://ijp.iranpath.org/article_31712_a890453dcbe18168f2218e5b67ab4e0d.pdf ER -