TY - JOUR ID - 254730 TI - KRAS Protein Expression in Oral Squamous Cell Carcinoma: A Potential Marker for Progression and Prognosis JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - El-hanbuli, Hala M. AU - Abou Sarie, Mostafa A. AD - Department of Pathology, Faculty of Medicine, Fayoum University, Egypt Y1 - 2022 PY - 2022 VL - 17 IS - 4 SP - 464 EP - 474 KW - Bcl2 KW - Cyclin D1 KW - Ki-67 KW - KRAS KW - Oral Squamous Cell Carcinoma DO - 10.30699/ijp.2022.550727.2856 N2 - Background & Objective: Emerging evidence suggests that KRAS could play an important role in squamous cell carcinoma; however, its role in oral squamous cell carcinoma (OSCC) is largely unknown. The aim of the current study was to investigate the expression of KRAS, Ki-67, Cyclin D1, and Bcl2 in OSCC and their association with clinicopathological features. Methods: Forty paraffin blocks of retrospective histologically diagnosed cases of OSCC and 20 blocks of oral leukoplakia with epithelial dysplasia were obtained from two hospitals between 2018 and 2021. The paraffin-embedded tissue was analyzed for the expression of KRAS for oral epithelial dysplasia and OSCC, and ki-67, Cyclin D1, and bcl2 were analyzed only for OSCC. The results were correlated with each other and with different clinicopathological features and were statistically analyzed. Results: KRAS expression was significantly associated with histological tumor grade, tumor extent, presence of nodal and distant metastasis, pathological stage, and the presence of lymphovascular invasion (P=<0.001, 0.001, 0.001, 0.009, <0.001, and <0.001, respectively). The KRAS expression was positively correlated with the histological grade, tumor extent, nodal status, and the pathological stage (r=0.712, 0.649, 0.646, and 0.865, respectively). A positive correlation was also found with the expression of Bcl2, Cyclin D1, and Ki-67 (r=0.81, 0.723, and 0.698, respectively). The KRAS expression in oral epithelial dysplasia was significantly lower than that in OSCC (P=0.003). UR - https://ijp.iranpath.org/article_254730.html L1 - https://ijp.iranpath.org/article_254730_cdd5fa2c25fe9377b615bc5e54850796.pdf ER -