TY - JOUR ID - 254062 TI - Study of Podoplanin Expression in Head and Neck Squamous Cell Carcinoma JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - JIbi, Anjali Mary AU - Basavaraj, Vijaya AD - Department of Pathology, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India Y1 - 2022 PY - 2022 VL - 17 IS - 3 SP - 275 EP - 284 KW - Head and Neck Squamous Cell Carcinoma KW - Podoplanin KW - Lymph node metastasis DO - 10.30699/ijp.2022.547004.2809 N2 - Background & Objective: Head and Neck Squamous cell carcinoma (HNSCC) is one of the leading cancers worldwide. Cervical lymph node metastasis is the most adverse prognostic factor for patients with HNSCC. As there are no reliable factors in predicting lymph node metastasis, recent researchers focus on identifying various metastasis markers that will aid treatment selection. Podoplanin is a recent marker strongly associated with lymph node metastasis, aggressive tumor behavior, and poor prognosis. The expression of podoplanin in human squamous cell cancers and its association with cancer cell motility suggest a possibility that it could be used as a biomarker to predict lymph node metastasis. To study the expression of podoplanin in head and neck squamous cell carcinoma, determine its association with clinicopathological variables, and predict its use as a biomarker in predicting lymph node metastasis.Methods: The present study was conducted in a tertiary care hospital. Podoplanin expression was studied in 45 cases of HNSCC and its association with clinicopathological variables. The predictive power of podoplanin was further analyzed using univariate and multivariate logistic regression analysis. The positive and negative predictive values of podoplanin were determined concerning the presence or absence of lymph node metastasis.Results: Podoplanin expression is significantly associated with histological grade (P=0.03) and lymph node metastasis (P=0.01). In logistic regression analysis, podoplanin expression (Odds Ratio: 5.66, Confidence Interval: 1.23 -25.87, P=0.02) was a significant independent predictor of lymph node metastasis.Conclusion: Our study demonstrates that podoplanin provides prognostic information and predicts lymph node metastasis which was consistent with our studies in the literature. Thus, podoplanin may help better stratify patients selected for elective neck node dissection in early tumor stages and clinically negative regional disease. UR - https://ijp.iranpath.org/article_254062.html L1 - https://ijp.iranpath.org/article_254062_53e51bb19ec94c85500b7146c9e76d12.pdf ER -