TY - JOUR ID - 25038 TI - Clinical Manifestations and Diagnosis of Non-Alcoholic Fatty Liver Disease JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Khoonsari, Mahmoodreza AU - Mohammad Hosseini Azar, Mohammadreza AU - Ghavam, Ramak AU - Hatami, Khadijeh AU - Asobar, Mosa AU - Gholami, Ali AU - Rajabi, Abdolhalim AU - Safarnezhad Tameshkel, Fahimeh AU - Amirkalali, Bahare AU - Sohrabi, Masoudreza AD - Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran. AD - Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran AD - Faculty of Iranian Traditional Medical, Tehran University of Medical Sciences AD - Dept. of Public Health, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran AD - Zabol University of Medical Sciences, Zabol, Iran AD - Gastrointestinal and liver diseases research center, firoozgar hospital, Iran University of Medical Sciences, Tehran, Iran. AD - Gastrointestinal and Liver Disease Research Center (GILDRC), Iran University of Medical Sciences, Tehran, Iran Y1 - 2017 PY - 2017 VL - 12 IS - 2 SP - 99 EP - 105 KW - NAFLD KW - Clinical manifestations KW - Sleep KW - anxiety DO - 10.30699/ijp.2017.25038 N2 - Background & Objective: Nonalcoholic fatty liver diseases (NAFLD) is the major cause of hepatocellular carcinoma and increases the risk of mortality. Understanding the trends of its clinical and biochemical changes is essential to identify patients with NAFLD that are at the greatest risk of nonalcoholic steatohepatitis (NASH) and cirrhosis in Iran. Methods: Patients with NAFLD confirmed by ultrasonography were enrolled into the current study. They had negative serologic markers of viral or autoimmune hepatitis, no findings in favor of metabolic liver disease, and had not received medications that affect liver, such as silymarin and Ursobil. Biochemical and clinical symptoms and histological variables were evaluated for each patient. Descriptive statistics were used to compute all variables. Results: A total of 206 patients, including 109 male and 97 female, with the mean age of 41.2 years were enrolled. The number of patients without obesity and diabetes were 34 (16.4%) and 48 (23.1%), respectively. Sleep disorder, delayed sleep, daytime sleepiness, and late dinner were noticeably common in patients with NAFLD. Furthermore, anxiety, thirst sensation, bloating, warming sensation, defecation disturbances, and upper abdominal pain were common among patients with NAFLD. Conclusion: NAFLD is a heterogeneous disorder with vast clinical presentations. It seems that anxiety and gastrointestinal problem are common among such patients. Moreover, inadvertent sleep could have a considerable effect on developing NAFLD. Patients with diabetes have more severe NAFLD, based on clinical and histological findings. UR - https://ijp.iranpath.org/article_25038.html L1 - https://ijp.iranpath.org/article_25038_576a80a01df89c69a3867a9bb86aaef0.pdf ER -