TY - JOUR ID - 24868 TI - Platelet Septic Transfusion Reactions in Patients With Hemato-Oncological Diseases JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Razjou, Farhad AU - Dabir Moghaddam, Abolfazl AU - Karimi, Gharib AU - Zadsar, Maryam AD - Blood Transfusion Research Centre, High institute for Research and Education in transfusion Medicine. Tehran, Iran Y1 - 2017 PY - 2017 VL - 12 IS - 2 SP - 112 EP - 118 KW - Septic transfusion reaction KW - Citrobacter Frundei KW - Patients With Leukemia or Lymphoma KW - Platelet concentrates KW - hemovigilance DO - 10.30699/ijp.2017.24868 N2 - Background & Objective: Bacterial, contamination of blood components are a significant risk for transfusion reactions. Inherently, platelet concentrates (PCs) are vulnerable to bacterial contamination, due to the storage condition of processed PCs at room temperature, which provide very suitable conditions for the proliferation of microorganisms. The current study aimed at investigating the transfusion associated septic reaction rate in patients with hemato-oncological diseases in Imam Khomeini Hospital, Tehran, Iran, and identifying the contaminating bacteria. Methods: A total of 3056 adult patients of the Cancer Center of Imam Khomeini Hospital in Tehran transfused with PCs were studied based on the clinical symptoms of septic transfusion reaction from June 1, 2010 to May 31, 2011. Patient presented with the criteria of reaction and the residual components were evaluated for bacterial contamination by Bac T/Alert system. Results: Patients with leukemia or lymphoma transfused with random-donor PCs were evaluated the signs and symptoms of transfusion reaction occurred only in 12 (%0.4) cases. Automated cultivation found 3 positive blood cultures. Among these a male recipient was categorized as possible septic transfusion reaction and Citrobacterfreundii was isolated from blood sample. Conclusion: Appropriate clinical utilization of PCs transfusion, and ongoing vigilance to recognize, investigate, promptly treat, and report all suspicious transfusion reactions are necessary to manage the transfusion complication including transfusion-transmitted infections (TTI). UR - https://ijp.iranpath.org/article_24868.html L1 - https://ijp.iranpath.org/article_24868_f38bc4430794631f0e8bc2d5089fbe98.pdf ER -