TY - JOUR ID - 247897 TI - Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- Review JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Bahadori, Moslem AU - Azizi, Mohammad Hossein AU - Dabiri, Shahriar AU - Bahadori, Neda AD - Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Academy of Medical Sciences of I.R. Iran, Tehran, Iran AD - Department of Pathology, Pathology and Stem cells Research Center, Afzalipour Medical School, Kerman University of Medical Sciences, Kerman, Iran AD - Tehran University of Medical Sciences, Tehran, Iran Y1 - 2022 PY - 2022 VL - 17 IS - 1 SP - 1 EP - 7 KW - Endotheliopathy KW - Nucleolus KW - Nucleolopathy KW - viral infection DO - 10.30699/ijp.2021.540305.2744 N2 - The nucleolus is a subcellular membraneless structure of eukaryotic cells. In 1965, in a world’s southern summer summit in Uruguay, the role of the nucleolus as the site of ribosome synthesis, biogenesis, and processing of tRNA was conclusively established. Today, accumulating evidence confirm the multiple functions of the nucleolus, including tRNA precursor processing, cell stress sensing, as well as being influential in gene silencing, senescence, lifespan, DNA damage response (DDR), and cell cycle regulation. Therefore, nucleolopathy is observed in various human diseases. Modern advances have provided fundamental insights concerning how and why the nucleolus is targeted by different pathogenic organisms. Viruses are major organisms that disrupt the normal function of the nucleus and produce nucleoli proteins for facilitating the replication of viruses causing viral infections. In this review, we focus on the possible role of nucleoli upon coronavirus infections, in particular coronavirus disease 2019. UR - https://ijp.iranpath.org/article_247897.html L1 - https://ijp.iranpath.org/article_247897_00666ad566fb94d4da7885219bafe331.pdf ER -