TY - JOUR ID - 244478 TI - Severe Prekallikrein Deficiency Associated with Low Level of Factor XII: A Case Report JO - Iranian Journal of Pathology JA - IJP LA - en SN - 1735-5303 AU - Shahbazi, Massoumeh AU - Ahmadinejad, Minoo AU - Fakhrzadegan, Shahnaz AD - Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran AD - Department of Hematology and Oncology, School of Medicine, Iran University of Medical Science, Tehran, Iran Y1 - 2021 PY - 2021 VL - 16 IS - 3 SP - 332 EP - 336 KW - Factor XII deficiency KW - Prekallikrein deficiency KW - Prolonged aPTT DO - 10.30699/ijp.2021.131638.2463 N2 - Hereditary deficiency of plasma prekallikrein (PPK) is a rare autosomal recessive disease. The affected patients are often asymptomatic and diagnosed incidentally during preoperative investigations or during hospitalization by isolated prolongation of activated partial thromboplastin time (aPTT). In this article, we report, a 46-year-old woman who was candidate for two invasive procedures (thyroid FNA and hysterectomy) and underwent preoperative evaluation.  Due to prolonged aPTT with normal PT she was referred to the IBTO reference coagulation laboratory for specific coagulation assays. Ultimately, the examinations revealed severe PPK deficiency (<1%) with partial deficiency of factor XII level (25%). UR - https://ijp.iranpath.org/article_244478.html L1 - https://ijp.iranpath.org/article_244478_4013c29b2aa87bd7f86e1a5fb8e5e36a.pdf ER -