%0 Journal Article %T Chromosomal Analysis Of Couples With Bad Obstetric Histoty %J Iranian Journal of Pathology %I Farname Inc in collaboration with Iranian Society of Pathology %Z 1735-5303 %A Malekasgar, Ali Mohamad %A Esmaeil Motlagh, Mohamad %A Hashemi Tabar, Mahmood %A Ghafari, Mohamad Ali %D 2006 %\ 06/01/2006 %V 1 %N 3 %P 91-98 %! Chromosomal Analysis Of Couples With Bad Obstetric Histoty %K Obstetric history %K Karyotype %K Chromosomal abmormalities %K abortion %R %X Background and Objective: Pregnancy termination and recurrent abortion are one of the common complications during pregnancy and in patients with a bad obstetric history. Materials and Methods: In this study, a total of 154 individuals including 75 couples four single women from different communities and with various incomes were investigated chromosomal abnormalities using blood culture and chromosomal banding technique. Results: Chromosomal analysis of these patients revealed three abnormal karyotypes (3.8%) in three women and two abnormal karyotypes in conceptions. Two of these couples had consanguineous marriage and the remaining women included one isochromosome for X [46, x,I (xq)], two translocations [45, xx, t (15:21)] and [46, xx, t (7:14)], one trisomy ‘21’ (47, xx, +21), and a ring chromosome (46, xx, r(X). In addition, 27 conceptions had been reported for these five couples. These included 23 abortions with 18 of them within first trimester (78.26%) and four of them had abortions within second trimester (21.74%), one had a normal child, three had abnormal children, and one with stillbirth. Conclusion: It was found out that abnormal karyotype is present in 3.8% of patients with a bad obstetric history. There was also a close relationship between number of deliveries and abortions and this relation was statistically significant (p<0.01). In addition, consanguinity was also related with number of abnormal children (p<0.05). There was also a significant relationship between consanguinity and first trimester abortions (p<0.05). Therefore, in couples with more than three abortions, especially within first trimester, chromosomal evaluation can have a diagnostic value.   %U https://ijp.iranpath.org/article_8910_c1549483ca7d121b06d9b262d514930d.pdf