%0 Journal Article %T Metachronous Malignant Fibrous Histiocytoma- A Rare Case Report %J Iranian Journal of Pathology %I Farname Inc in collaboration with Iranian Society of Pathology %Z 1735-5303 %A Rawal, Gireesha %A Zaheer, Sufian %A Yadav, Amit %A Dhawan, Indrani %D 2018 %\ 10/01/2018 %V 13 %N 4 %P 474-478 %! Metachronous Malignant Fibrous Histiocytoma- A Rare Case Report %K Metachronous %K Malignant fibrous histiocytoma %R %X Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. Distant metastases are developed in 30–40% of patients with MFH, with the most common site being the lung. However, metachronous MFH has not been reported previously in literature. This report describes a case of a 30-year-old man, who had two metachronous thigh tumors, both of which were confirmed to be MFH on histopathology and immunohistochemistry evaluations. A contemporary multidisciplinary approach to therapy including surgery, radiation and chemotherapy was advocated. Two primary sites of MFH raised the possibility of a genetic abnormality that could predispose such a patient to develop multiple primary sites of the same tumor. %U https://ijp.iranpath.org/article_32430_b8ed346947fbdd655750f3a65aa263fc.pdf