@article { author = {Moinfar, Farid}, title = {Is “Basal-like” Carcinoma of the Breast a Distinct Clinicopathologic Entity? A Critical Review with Cautionary Notes}, journal = {Iranian Journal of Pathology}, volume = {2}, number = {4}, pages = {127-143}, year = {2007}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {}, abstract = {This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. The key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. It concludes that “basal-like” carcinomas do not reflect a single, biologically uniform group of breast cancers and show significant variations in their phenotypes, grades, immunoprofiles, and clinical behavior, just as a wide range of subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Welldesigned studies with comparison of low grade non-basal versus low grade basal and high grade non-basal versus high grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathologic entity.  }, keywords = {Breast cancer,Basal-like carcinoma,Microarray Analysis,Molecular,Classification Tumors,Immunohistochemistry}, url = {https://ijp.iranpath.org/article_8982.html}, eprint = {https://ijp.iranpath.org/article_8982_48f81aa2e3db44f616f49cbdcaf94e1f.pdf} }