@article { author = {Sanei, Mohammad Hossein and Mirmosayyeb, Omid and Chehrei, Ali and Ansari, Jamshid and Saberi, Elahe}, title = {5-Year Survival in Gastric Adenocarcinoma with Epithelial and Stromal Versican Expression}, journal = {Iranian Journal of Pathology}, volume = {14}, number = {1}, pages = {26-32}, year = {2019}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {10.30699/ijp.14.1.26}, abstract = {Background & Objective: Gastric cancer is the second most frequent cause of cancer death worldwide, despite differences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival rate when coupled with early-stage diagnosis. Versican, a member of the aggregating chondroitin sulfate proteoglycans family, is accumulated predominantly in the tumor stroma. The aim of our study was to investigate versican expression in gastric adenocarcinoma. Methods: In this study we investigated 80 patients with gastric adenocarcinoma who underwent gastrectomy. Each sample was obtained from paraffin-embedded resected specimens of the stomach after histopathological diagnosis. Patient follow-up was performed every 3 months after the beginning of data collection. Survival analysis was calculated using the Kaplan-Meier method for univariate analysis.Results: Out of 80 patients with gastric adenocarcinoma, 76 cases (76.3%males and 23.7% females) completed the follow-up period. Positive versican expression in tumor epithelial and stromal cells was found in 39.5% and 22.4% of tumors, respectively. Shorter survival was observed among patients whose gastric adenocarcinoma expressed epithelial or stromal versican.Conclusion: In summary, the present study suggests that versican is likely a prognostic biomarker that predicts a poor outcome in patients with gastric adenocarcinoma. Comprehensive studies with larger sample sizes are needed.}, keywords = {Stomach Neoplasms Adenocarcinoma,Survival,Versican}, url = {https://ijp.iranpath.org/article_33636.html}, eprint = {https://ijp.iranpath.org/article_33636_f40052f47835c1b8d89a5dcc682ef466.pdf} }