@article { author = {Jafarian, Amir Hossein and Mirshekar, Khatoone and Etemad, Sare and Jafaripour, Masoumeh and Darijani, Mansoore and Sheikhi, Maryam and Ayatollahi, Hossein and Shakeri, Sepideh and Shams, Seyyede Fatemeh and Davari, Saeed}, title = {Molecular Status of BRAF Mutation in Prostate Adenocarcinoma: The Analysis of 100 Cases in North-East of IRAN}, journal = {Iranian Journal of Pathology}, volume = {13}, number = {4}, pages = {415-421}, year = {2018}, publisher = {Farname Inc in collaboration with Iranian Society of Pathology}, issn = {1735-5303}, eissn = {2345-3656}, doi = {}, abstract = {Background and Objective: BRAF mutations were studied in various populations for prostate carcinoma (PC); however, mutations in BRAF gene are unusual compared to KRAS. Oncogenic activating of BRAF mutations were studied lately in almost 0%-10% of prostate cancer cases. Methods: In this retrospective study, we gathered 100 formalin-fixed paraffin-embedded samples of prostate adenocarcinoma. A hundred archived samples of adjacent benign prostatic hyperplasia were chosen as normal control. This study was done in pathology laboratory of Qaem Hospital during 2013-2015.Results: Total number of 200 PC and normal cases was investigated for BRAF V600E mutation. The BRAF V600E mutation was found in only 4 patients but it was not detected in normal cases. There were no significant differences between patient and control groups for this mutation (P>0.99). The frequency of BRAF V600E mutation was not significant in different age groups (P>0.285); the most frequency was related to the age range of 71-80. No significant difference was observed between tumor grade and BRAF mutation (P=0.21).Conclusion: According to our findings, BRAF gene mutations did not play essential role in PC. Therefore, anti-BRAF (V600E) could not be considered as a proper target for therapy.}, keywords = {BRAF mutation,Prostate adenocarcinoma,Gleason score}, url = {https://ijp.iranpath.org/article_32421.html}, eprint = {https://ijp.iranpath.org/article_32421_82193c9777d5dda2f7467737aa7251dc.pdf} }