Validation of Pathological Medical Record: A Process
Viroj
Wiwanitkit
1. Thai POCT forum coordinator, Bangkok, Thailand
2. Editorial Board Member, Iranian Journal of Pathology
author
text
article
2012
eng
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
1
2
https://ijp.iranpath.org/article_8374_d592bd7934110fbd6053ac5bbcad21aa.pdf
Accuracy of Frozen Sections
Fariba
Abbasi
Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
author
Zahra
Yekta
Department of Community Medicine, Faculty of Medicine, Urmia University of Medical Sciences,
Urmia, Iran
author
Adel
Aryan
Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
author
text
article
2012
eng
Background and Objective: Intraoperative consultation by frozen section is a high – risk procedure with important consequences. Therefore, it is critical to determine efficiency of frozen section performance periodically. This study was performed to determine the accuracy of frozen section in Urmia University of Medical Sciences.
Materials & Methods:Inthis cross sectional study, we compared the results of 200 consecutive cases of frozen sections with their final permanent section diagnoses in teaching hospitals of Urmia University of Medical Sciences during March 2001 to March 2008.
Results: A total of 155 neoplastic and 45 nonneoplastic specimens were studied. The overall accuracy of frozen sections was 96.5%. In diagnosis of neoplastic lesions, sensitivity, specificity, positive and negative predictive values and accuracy were 93.1%, 97.7%, 96%, 95% and 95.9%, respectively.
Conclusion: In this university interpretation of frozen sections is done with high accuracy and is valuable to help surgeons to plan the best management of the operation.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
3
8
https://ijp.iranpath.org/article_8394_aca9dc382102fd6d99c74d2d8e366600.pdf
Frequency of Human T-Cell Lymphotropic Virus (HTLV) Type 1 and 2 Infection in HIV Infected Patients
Amitis
Ramezani
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
author
Arezoo
Aghakhani
Iranian Society for Support of Patients With Infectious Diseases, Tehran, Iran
author
Mohammad
Banifazl
Dept. of Microbiology, Alzahra University, Tehran, Iran
author
Zahra
Boland-Ghamat
Iranian Research Center for HIV/AIDS, Tehran, Iran
author
Maryam
Foroughi
Iranian Research Center for HIV/AIDS, Tehran, Iran
author
Latif
Gachkar
Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti
University of Medical Sciences, Tehran, Iran
author
Akbar
hadem-Sadegh
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
author
Minoo
Mohraz
Iranian Research Center for HIV/AIDS, Tehran, Iran
author
text
article
2012
eng
Background and Objectives: Human T-cell lymphotropic viruses (HTLV) type 1 and 2 are retroviruses that share the same routes of transmission as human immunodeficiency virus (HIV). As a consequence of epidemiologic similarities, HIV and HTLV-1/2 co-infection is frequent. Due to the limited data, this study assessed the seroprevalence of HTLV-1/2 infections in HIV infected patients in Tehran, Iran.
Materials and Methods: This case-control study was carried out in 180 HIV infected patients from Iranian HIV/AIDS Research Center in Tehran and 117 matched healthy controls. The serum samples were checked with enzyme-linked immunosorbent assay (ELISA) for anti HTLV-1/2.
Results: A total of 180 HIV positive patients with mean age 36.9±9.2 years and 117 matched controls were enrolled in the study. All cases and controls were negative for HTLV-1/2 infection.
Conclusion: HTLV-1/2 infection is negligible in HIV infected patients in Tehran, Iran, although intravenous drug use is the most common route of HIV transmission in our study subjects.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
9
13
https://ijp.iranpath.org/article_8397_11569bc4d2e414eb0874682252e4d032.pdf
Reduced Serum Homocysteine Levels in Diabetic Patients
Forough
Kajbaf
Dept. of Physiology, Islamic Azad University, Qom, Iran
author
Mohammad
Ali Ghaffari
Razi Clinical Lab., Ahwaz, Iran
author
Mohammad Javad
Kajbaf
Dept. of Microbiology, Jondishapour University of Medical Sciences, Ahwaz, Iran
author
text
article
2012
eng
Background and Objectives: Type 2 diabetes is the most prevalent form of diabetes mellitus and is associated with a variety of complications. Homocysteine is an important independent risk factor for atherosclerotic diseases in both diabetic and non diabetic subjects. The association between these two is still unclear. The aim of this study was to assess the serum homocysteine levels in uncomplicated type 2 diabetic patients and control subjects.
Materials and Methods: Eighty five diabetic patients and 85 healthy control subjects with the mean age of 57.65 and 57.68 years, respectively, were selected during 2010 in Ahwaz City, southwest of Iran. Serum glucose, lipids and lipoproteins were measured by standard enzymatic techniques and homocysteine levels by enzyme –linked immunosorbent assay method.
Results: In patients as a whole and with respect to the gender, homocysteine levels were generally lower than controls. Compared to other studies, homocysteine levels ranging from 12.19 to 18 µmol/l were slightly higher in both population.
Conclusion: Homocysteine levels, however, were compatible with normal range of adults. The patients were not nephropathic and it is most likely that this is the main reason for maintaining the normal levels. Slightly higher levels of homocysteine in the region are due to multiple genetic and environmental factors.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
14
18
https://ijp.iranpath.org/article_8398_3aa953e1e43fbc8fe6de8206383534dc.pdf
Beta-Thalassemia Carrier Detection by NESTROFT: An Answer in Rural Scenario?
Indranil
Chakrabarti
Dept. of Pathology, North Bengal Medical College, Siliguri, India
author
Swapan
Kumar Sinha
Dept. of Pathology, Medical College, Kolkata, India
author
Nilanjana
Ghosh
Dept. of Community Medicine, West Bengal University of Health Sciences, Siliguri, India
author
Bidyut
Krishna Goswami
Dept. of Pathology, North Bengal Medical College, Siliguri, India
author
text
article
2012
eng
Background and Objectives: Beta-thalassemia continues to be a cause of significant burden to the society particularly in the poorer developing countries. Although sophisticated methods of screening have become available, a hunt for a cheap, rapid, objective screening method still remains elusive. Thus, the objectives are to study the validity of Naked-Eye-Single-Tube-Osmotic-Fragility-Test (NESTROFT) in detection of beta-thalassemia carrier state, to assess the prevalence of beta-thalassemia trait among antenatal mothers in the region and also to find out the effect of concurrent iron deficiency on the hematological parameters in these cases.
Materials and Methods:A total of 500 antenatal mothers in a rural tertiary care hospital were selected for the study. Their blood samples were subjected to NESTROFT, complete hemogram, reticulocyte counts and hemoglobin variant studies by electrophoresis and by high pressure liquid chromatography (HPLC). Serum ferritin estimation was done in cases diagnosed as beta-thalassemia trait. The results were analyzed statistically.
Results: A prevalence of 3.4% of beta-thalassemia trait and 0.6% of E-beta-thalassemia were observed among the study population. NESTROFT showed an overall sensitivity and specificity of 95% and 95.8% respectively in detection of heterozygous and double heterozygous states of beta-thalassemia. The various RBC indices were significantly (P <0.05) lower in carriers with concurrent iron deficiency. A co-existent iron deficiency did not preclude a diagnosis of beta-thalassemia carrier state.
Conclusions: NESTROFT appears to a valid test in rural setting with financial constraints. The hematological parameters in iron deficient beta-thalassemic carriers significantly differed from their iron replete counterparts but did not cause problem in diagnoses.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
19
26
https://ijp.iranpath.org/article_8399_db997dabcfb868dd9db46f56d0ec0757.pdf
Tetanus and Diphtheria Seroprevalence in Patients Infected With Human Immunodeficiency Virus
Ali
Eslamifar
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
author
Amitis
Ramezani
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
author
Mohammad
Banifazl
Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran
author
Arezoo
Aghakhani
Clinical Research Dept., Pasteur Institute of Iran, Tehran, Iran
author
text
article
2012
eng
Background and Objectives: HIV infected patients are at risk for vaccine-preventable infections such as tetanus and diphtheria (Td). In these patients, these antibodies tend to decline faster. Due to the limited data, this study assessed the seroprevalence of tetanus and diphtheria antibodies in HIV infected patients in Tehran, Iran.
Materials and Methods: This case-control study was carried out in 180 HIV infected patients from Iranian HIV/AIDS Research Center in Tehran and 90 matched healthy controls. The serum samples were checked with ELISA for tetanus and diphtheria antibodies.
Results:A total of 180 HIV positive patients with mean age 36.9±9.2 years and 90 matched controls were enrolled in the study. Tetanus antibody was lower in HIV group when compared with control group. There was no significant difference in the mean serum levels of diphtheria antibody in HIV positive patients when compared with the controls. About 93.3% and 96.6% of HIV infected patients had protective diphtheria and tetanus antibodies respectively. Mean tetanus and diphtheria antibodies levels were not significantly different based on the circulating CD4+ cells.
Conclusion: HIV positive cases, who had received primary Td vaccination before they contracted HIV infection, can be expected to be protected against diphtheria, whereas revaccination against tetanus must be considered.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
27
31
https://ijp.iranpath.org/article_8400_320d36320723781a89fb6d937b0aa9fb.pdf
Urinary Tract Infections Caused By Group B Streptococcus in Adult Women: Survey of 11800 Urine Culture Results
Mohammad
Rahbar
Dept. of Microbiology, Health Reference laboratory, Ministry of Health and Medical
Education, Tehran Iran
author
Massoud
Hajia
Antibiotic Resistance Research Center, Tehran University of Medical Sciences, Tehran, Iran
author
Mona
Mohammadzadeh
Dept. of Microbiology, Milad Hospital, Tehran Iran
author
text
article
2012
eng
Background and Objective: Early diagnosis of Streptococcus agalactiae remains difficult, since symptoms are very nonspecific. Its frequency has not been completely investigated in urinary tract pathogen of pregnant ant and non pregnant women in Iran. The aim of this study was determining the frequency of Group B Streptococci in female patients.
Materials and Methods: A Total of 11800 urine specimens were received from female out-patients admitted during June till December 2010. Group B Streptococci isolates were confirmed by typical colony morphology, and identified by differential tests as well as by the growth characteristics in chromoagar. A provisional urinary tract infection diagnosis was defined by the presence of single group B Streptococci (>10 CFU/liter) with at least one of urinary tract infection symptom. Susceptibility testing was carried out by disk diffusion method.
Results: Of all specimens 498 specimens (4.22%) yielded significant bacteriuria caused by group B Streptococci. The mean age of these patients were 26.6 + 19.37. Pregnant patients were 3.82% and the rest were non-pregnant. Antibiotic susceptibility test revealed that vancomycin, clindamycin and cefazolin had the lowest and penicillin showed the highest resistant rate.
Conclusion: Pattern onantibiotic susceptibility test showed high resistant rate to some antibiotic that made it difficult for pregnant patients, although its frequency was low. It was not possible to compare the antibiotic susceptibility pattern of pregnant women with non-pregnant because of the low number of pregnant women registered in this study.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
32
37
https://ijp.iranpath.org/article_8401_160e3ad082a39712a87a488e52c33978.pdf
Fasciitis Ossificans of the Larynx
Etrat
Javadi Rad
Dept. Of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran
author
Azadeh
Almasi
Dept. Of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran
author
Behzad
Khoshraftar
Dept. Of Otolaryngology, Tischreen University of Medical Sciences, Lattakia, Syria
author
text
article
2012
eng
We describe a rare case of laryngeal fasciitis ossificans. A 58-year-old man presented with hoarseness and a nodule was found in the larynx. Excisional biopsy was performed, and follow-up laryngoscopy showed complete resolution of this reactive lesion, and normal laryngeal function. The 0.6 cm diameter nodule was well circumscribed and histologically, the lesion was composed of uniform woven bone trabeculae with rimming of osteoblasts and cellular stroma. At the periphery, uniform spindle cells actively proliferated in edematous stroma. Spindle cells were immunoreactive for vimentin and α-smooth muscle actin, suggesting myofibroblastic differentiation. Fasciitis ossificans is histologically identical to myositis ossificans, but tends to present no zonation phenomenon. Fasciitis ossificans is a rare form of heterotopic bone formation, commonly presenting with signs of local inflammation or pain. This patient's successful outcome suggests that conservative resection may be both diagnostic and curative.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
38
42
https://ijp.iranpath.org/article_8402_f3d7c77e9496834500d62758994b844c.pdf
A Widely Destructive Leiomyoma of the Nasal Septum – An unusual presentation
Nishat
Afroz
Dept. of Pathology, Aligarh Muslim University, Aligarh, India
author
Nazoora
Khan
Dept. of Pathology, Aligarh Muslim University, Aligarh, India
author
Syed Abrar
Hasan
Dept. of Otorhinolaryngology, Aligarh Muslim University, Aligarh, India
author
Amit
Kumar
Dept. of Pathology, Aligarh Muslim University, Aligarh, India
author
text
article
2012
eng
Leiomyoma of nasal cavity is a rare and benign tumor of smooth muscle origin that uncommonly arises from the nasal septum. We present an unusual case of histopathologically diagnosed locally extensive leiomyoma of the nasal septum which was clinically and radiologically misdiagnosed as malignancy of the nasal cavity. This case report emphasizes the rare occurrence of this entity at this site and highlights the need to consider this pre-operatively to avoid its associated significant bleeding and altogether different clinical management of this benign entity.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
43
47
https://ijp.iranpath.org/article_8403_d95bf94fdd73b2c27c0a3f96130e8eb0.pdf
Angiomyoma of the Hard Palate
Pouria
Motahhary
Dept. of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran
author
Mojgan
Ghazi
Dept. of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran
author
Raziye
Jabbarian
Dept. of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran
author
text
article
2012
eng
Leiomyoma is a rare benign neoplasm deriving from smooth muscle. Vascular leiomyoma is its most common subtype in the oral cavity. It may appear at any age with the greatest incidence in the 4th and 5th decade of life. The common manifestation is a slow-growing, asymptomatic, submucousal mass. The diagnosis is only through microscopic examination requiring special staining. Treatment of choice is surgical excision and no recurrence is usually seen. In this report, we present a case of angiomyoma in the midline of hard palate with description of its clinical, histological and immunohistochemical characteristics.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
48
52
https://ijp.iranpath.org/article_8404_9ee43bfc4a1c6a750cef0a985ba3afb1.pdf
Scrotal Aspergillosis Associated with Fournier’s Gangrene in a Patient with Cirrhosis
Mary
Mathew
Dept. of Pathology, Manipal University, Manipal, India
author
Padma
Priya
Dept. of Pathology, Manipal University, Manipal, India
author
Stanley
Mathew
Dept. of Surgery, Manipal University, Manipal, India
author
text
article
2012
eng
Pulmonary aspergillosis is a well known entity occurring in immunocompetent persons. Cutaneous aspergillosis, on the other hand, has been described in cases of suppressed immunity. Recently, invasive aspergillosis has been reported in patients with subtle immune dysfunction such as those with critical illness and advanced cirrhosis. We report a case of scrotal aspergillosis in association with Fournier’s gangrene and necrotizing fasciitis in a patient with cirrhosis.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
53
57
https://ijp.iranpath.org/article_8405_a4c8c80584b47e99ee5092d367dd63bd.pdf
Monoclonal Gammopathy of Undetermined Significance with Metastatic Carcinoma – A Rare Presentation
Priyanka
Joseph Koshy
Dept. of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India
author
Mijil
Anand Justin
Dept. of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India
author
Meenakshi
Vedavyasan
Dept. of Biochemistry, Pondicherry Institute of Medical Sciences, Pondicherry, India
author
Thomas
Alexander
Dept. of Gastroenterology, Pondicherry Institute of Medical Sciences, Pondicherry, India
author
Renu G’Boy
Varghese
Dept. of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India
author
text
article
2012
eng
The presence of a low level of M protein in the peripheral blood <3gm/dl which is below the required cut off for the diagnosis of plasma cell myeloma is known as monoclonal gammopathy of undetermined significance (MGUS). Elevated levels of serum M protein and detection of M band on serum protein electrophoresis (SPE) can occur in chronic diseases not related to B cell disorders and not always diagnostic for B cell dyscrasias. It can also be seen in non hematological malignancies as seen in our case. We present a case of MGUS in a 59yr male patient, previously diagnosed and surgically treated for carcinoma prostate and colon. Serum electrophoresis revealed an M Band – monoclonal protein of 1.9 gm/dl. Urine for Bence Jones proteins was negative and his skeletal X-rays did not reveal lytic lesions. Bone marrow aspiration revealed metastatic carcinoma. Plasma cells formed 1% of the bone marrow differential count.
Iranian Journal of Pathology
Farname Inc in collaboration with Iranian Society of Pathology
1735-5303
7
v.
1
no.
2012
58
62
https://ijp.iranpath.org/article_8406_a252452232afbe63f7d298da0cd85aa0.pdf