Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Head and Neck Pathology
Sclerosing Microcystic Adenocarcinoma of the Base of Tongue with Signet Ring-Like Cell Component: A Rare Case

Parisa Mokhles; Alireza Sadeghipour; Maryam Kadivar; Nasrin Shayanfar; Zahra Keshtpour Amlashi; Pegah Alizadeh Pahlavan; Ashkan Shafiei

Volume 19, Issue 1 , January 2024, , Pages 107-113


   Sclerosing microcystic adenocarcinoma (SMA) is an uncommon neoplasm of the oral cavity, with only 14 reported cases documented in the literature.We present a case of SMA in a 65-year-old woman with a history of high-grade lymphoma who developed clear cell changes in the deep muscular layer of the ...  Read More

Head and Neck Pathology
Advanced Sinonasal Malignant Melanoma; A Case Report

Parisa Khorasani Esmaili; Shahriar Dabiri; Ayeh Shamsadini; Tooraj Reza Mirshekari

Volume 18, Issue 3 , July 2023, , Pages 376-379


  Malignant melanoma of the sinonasal area is a rare tumor that arises from melanocytes in the nasal mucosa and is more aggressive than the cutaneous type with a poor prognosis.We report a 60-year-old female with the initial chief complaint of nasal cavity fullness, continuous epistaxis, and nasal bone ...  Read More

Head and Neck Pathology
MMP-9 and CCR7 as Possible Predictors of Lymph Node Metastasis in Laryngeal Squamous Cell Carcinoma

Lisnawati Rachmadi; Ela Laelasari; Yayi Dwina Bilianti; Kusmardi Kusmardi

Volume 18, Issue 2 , April 2023, , Pages 164-172


  Background & Objective: The expression of matrix metalloproteinase-9 (MMP-9) and chemokine receptor 7 (CCR7) is significantly associated with tumor invasion and metastasis. Little is known regarding the potential of these markers in predicting cancer metastasis in Laryngeal Squamous Cell Carcinoma ...  Read More

Head and Neck Pathology
Evaluation of Programmed Death - Ligand 1 (Pd-L1) Expression in Head and Neck Squamous Cell Carcinoma

Aarya Unnikrishnan; Vijaya Basavaraj

Volume 18, Issue 2 , April 2023, , Pages 193-201


  Background & Objective: Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly frequent malignancy worldwide and is also the leading cause of death. The prognosis for individuals with HNSCC remains dismal, with a five-year survival rate of less than 50%. The novel anti-PD-L1 immunotherapy is found ...  Read More

Head and Neck Pathology
Primary Parotid Angiosarcoma in a 66-year-old Man First Presented as Neck Lymph Node Metastasis: Pitfall Diagnosis with Review of Literature

Shokouh Taghipour Zahir; Fatemeh Derakhshani; Mohammad Reza Vahidy; Mojtaba Meybodian

Volume 18, Issue 2 , April 2023, , Pages 225-228


  Angiosarcoma is a malignant vascular tumor that occurs mostly in the soft tissues, skin, trunk, and limbs. Angiosarcoma of the parotid gland is a very uncommon and rare tumor.Herein, we presented a case of a 66-year-old man who was referred for a lump in his neck and his initial biopsy reported Castleman ...  Read More

Head and Neck Pathology
Salivary Gland Tumors in Iran: A Systematic Review of 2870 Cases Based on the New WHO Classification

Sahar Assar; Sepideh Assar; Heidar-Ali Mardanifard; Zohreh Jaafari-Ashkavandi

Volume 18, Issue 1 , January 2023, , Pages 1-11


  Background & Objective: There is no consensus on the prevalence of salivary gland tumors (SGTs) in Iran. Thus, we systematically reviewed the literature about the prevalence of SGTs in Iran and applied the last world health organization (WHO) classification.Methods: The systematic literature search ...  Read More

Head and Neck Pathology
YAP1 and P53 Expression in Papillary Thyroid Carcinoma

Dalia Nabil Abdelhafez; Maram Mostafa Ayoub; Samira A. Mahmoud; Hala M. El-hanbuli

Volume 18, Issue 1 , January 2023, , Pages 49-56


  Background & Objective: One of the most prevalent endocrine system cancers is papillary thyroid carcinoma, with complicated predisposing factors and pathogenesis. YAP1 (Yes-associated protein 1) is a well-known oncogene; its activity is increased in a variety of human malignancies and has recently ...  Read More

Head and Neck Pathology
Study of Podoplanin Expression in Head and Neck Squamous Cell Carcinoma

Anjali Mary JIbi; Vijaya Basavaraj

Volume 17, Issue 3 , July 2022, , Pages 275-284


  Background & Objective: Head and Neck Squamous cell carcinoma (HNSCC) is one of the leading cancers worldwide. Cervical lymph node metastasis is the most adverse prognostic factor for patients with HNSCC. As there are no reliable factors in predicting lymph node metastasis, recent researchers focus ...  Read More

Oral Pathology
Oral Microbiome in Head and Neck Cancers: An Insight, Are We Looking at a Step Beyond in Unraveling the Challenge?

Vaishnavi Vedam; Sivadas Ganapathy

Volume 17, Issue 2 , April 2022, , Pages 238-240


  Dear EditorHead and Neck Cancers (HNCs) contribute to one of the global health concerns and have been a challenge to oncologists for decades. Breakthroughs in research with evidence-based reports based on diagnostic and therapeutic approaches in clinical practice have been published to address patient ...  Read More

Head and Neck Pathology
Immunohistochemical Expression of Epithelial Mesenchymal Transition Proteins in Squamous Cell Carcinoma of the Oral Cavity

Hamideh Kadeh; Shirin Saravani; Ebrahim Miri-Moghadam

Volume 16, Issue 4 , August 2021, , Pages 354-361


  Background & Objective: Epithelial-Mesenchymal transition (EMT) is known to be a possible mechanism in tumor progression; however, there is insufficient evidence to support the contribution of this process in human cancers. The present study aimed to evaluate the expression of EMT markers in normal ...  Read More

Head and Neck Pathology
Reduced Expression of Galectin-8 May Contribute in Carcinogenic Pathway of Head and Neck Squamous Cell Carcinoma

Maryam Ghasemi; Laleh Vahedi Larijani; Jamshid azdani-Charati; Elham Kamali Hakim

Volume 16, Issue 2 , April 2021, , Pages 195-204


  Background & Objectives: Galectin-8 has relationships with cell growth and metastasis of some cancers. Due to controversy in the clinical significance of this protein in the cancer process, we investigated its roles in the development of head and neck squamous cell carcinoma. Methods: This study ...  Read More

Head and Neck Pathology
The Frequency of Human Papillomavirus Positivity in Iranian Patients with Head and Neck Squamous Cell Carcinoma

Mitra Rezaei; Mahboobeh Karimi-Galougahi; Azin Kheradmand; Mihan Pourabdollah Toutkaboni; Hassan Mir Mohammad Sadeghi; Alireza Abdollahi; Amirnader Emami Razavi; Ali Safavi Naini; Farahnaz Bidari- Zerehpoosh

Volume 16, Issue 1 , January 2021, , Pages 20-26


  Background & Objective: Human papillomavirus (HPV) has been associated with prognosis in patients with head and neck squamous cell carcinoma (HNSCC). Similar to the global studies, different prevalence rates of this viral infection have been reported in Iran. Therefore, we aimed to report the prevalence ...  Read More

Head and Neck Pathology
Cyclin D1 Expression in Patients with Laryngeal Squamous Cell Carcinoma

Vahid Zand; Fariba Binesh; Mojtaba Meybodian; Farzan Safi Dahaj; Arezoo Alamdar yazdi

Volume 15, Issue 3 , July 2020, , Pages 245-250


  Background & Objective: Laryngeal squamous cell carcinoma (LSCC) is considered to be one of the most common cancers of the head and neck, accounting for roughly 90% of all malignant tumors of the larynx. To have a timely diagnosis for a better and practical therapy, molecular markers have to be investigated. ...  Read More

Head and Neck Pathology
Salivary Duct Carcinoma with Late Distant Brain and Cutaneous Metastasis: A Case Report

Hassan Mir Mohammad Sadeghi; Abbas Karimi; Amirsina Rahpeima; Samira Derakhshan

Volume 15, Issue 3 , July 2020, , Pages 251-255


  Salivary duct carcinoma (SDC) is a rare and highly aggressive salivary gland tumor with poor prognosis, rapid growth, distant metastasis, early regional metastasis, and a high rate of recurrence. The parotid gland is the most common site of involvement, and the lungs and the bones are the most common ...  Read More

Head and Neck Pathology
Respiratory Epithelial Adenomatoid Hamartoma: A Very Rare Entity Originating from the External Auditory Canal

Behrouz Shokouhi; Parisa Mehrasa; Farzad Aslani

Volume 15, Issue 3 , July 2020, , Pages 256-258


  Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract. It is characterized by abnormal glandular formations with ciliated epithelium arising from the nasal cavity, paranasal sinuses and nasopharynx, but other locations have also been described. We ...  Read More