Volume 19 (2024)
Volume 18 (2023)
Volume 17 (2022)
Volume 16 (2021)
Volume 15 (2020)
Volume 14 (2019)
Volume 13 (2018)
Volume 12 (2017)
Volume 11 (2016)
Volume 10 (2015)
Volume 9 (2014)
Volume 8 (2013)
Volume 7 (2012)
Volume 6 (2011)
Volume 5 (2010)
Volume 4 (2009)
Volume 3 (2008)
Volume 2 (2007)
Volume 1 (2006)
Molecular Pathology
Pediatric Inflammatory Myofibroblastic Tumor of Rectosigmoid Junction: A Case Report and Review of the Literature

Mohammad Vaseie; Mahsa Soti Khiabani; Maryam Monajemzadeh; Hojatollah Raji; Fatemeh Zamani; Neda Pak

Volume 19, Issue 1 , January 2024, , Pages 132-136


  The occurrence of rectosigmoid junction inflammatory myofibroblastic tumor IMT is uncommon in children. This is a rare form of mesenchymal tumor, belonging to the category of soft tissue tumors, and can be found at any anatomical site from the central nervous system to the gastrointestinal tract.Our ...  Read More

Molecular Pathology
Different Isoforms of PML-RARA Chimeric Protein in Patients with Acute Promyelocytic Leukemia: Survival Analysis per Demographic Characteristics, Clinicohematological Parameters, and Cytogenetic Findings

Sarah Siahbani; Akbar Safaie; Masoumeh Faghih; Marzieh Hosseini; Afsaneh Fendereski; Behnaz Valibeigi; Ahmad Monabati

Volume 18, Issue 4 , October 2023, , Pages 456-475


  Background & Objective: Acute Promyelocytic Leukemia (APL) is a medical emergency with potentially fatal complications. APL primarily results from a chromosomal translocation (t(15;17)(q22;q21)), leading to the formation of the PML-RARA fusion gene with three possible isoforms. This study aims to ...  Read More

Molecular Pathology
Molecular Status of BRAF Mutation in Epithelial Ovarian Cancer: An Analysis of 57 Cases in the Northeast of Iran

Amirhossein Jafarian; Masoumeh Jafaripour; Masoumeh Gharib; Maryam Salehi; Nema Mohamadian Roshan; Sare Etemad; Khatoone Mirshekar; Maryam Sheikhi; Masoumeh Heidari; Behnaz Ahmadian; Zahra Khoshnegah; Hossein Ayatollahi; Payam Siyadat

Volume 18, Issue 2 , April 2023, , Pages 134-140


  Background & Objective: Epithelial ovarian cancer (EOC) is the most prevalent type of ovarian cancer. Previous studies have elucidated different pathways for the progress of this malignancy. The mutation in the B-Raf proto-oncogene, serine/threonine kinase (BRAF) gene, a member of the MAPK/ERK signaling ...  Read More

Molecular Pathology
A Preliminary Sequence Analysis of the Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) Carboxy-Terminal Region in Cervical and Ovarian Cancers

Fatemeh Hoseini Tabatabaie; Seyed Younes Hosseini; Seyed Mohammad Ali Hashemi; Akbar Safaie; Jamal Sarvari

Volume 18, Issue 1 , January 2023, , Pages 24-32


  Background & Objective: Epstein-Barr virus nuclear antigen-1 (EBNA1) is one of the most important proteins of Epstein-Barr virus (EBV) that might be mutated in various related cancers. The purpose of this study was to compare EBNA1 mutations in the C-terminal region between patients with cervical ...  Read More

Molecular Pathology
Angiomatoid Fibrous Histiocytoma, A Great Mimicker – A Short Series of 3 Cases with EWSR1 Fusion

Aparna Devi C; Ashwini Nargund; Geeta V Patil Okaly; Usha Amirtham

Volume 18, Issue 1 , January 2023, , Pages 108-115


  Angiomatoid Fibrous histiocytoma (AFH) is a rare soft tissue neoplasm that is often misdiagnosed initially. It is commonly encountered in the superficial extremities of children and young adults. It is composed of a nodular proliferation of bland looking spindled to ovoid cells, some with variant histology ...  Read More

Molecular Pathology
Genetic and Epigenetic Alterations in Parathyroid Neoplasms

Seyed Amir Miratashi Yazdi; Elham Nazar

Volume 17, Issue 4 , October 2022, , Pages 395-405


  The etiology of parathyroid carcinoma (PC) is largely unknown. Associations have been made with several inherited syndromes and with specific genetic lesions. The management of PC is challenging for clinicians. The complexity of molecular phenotypes increases with tumor aggressiveness. Lack of parafibromin ...  Read More

Molecular Pathology
MIF and MMP-9 Serum Changes in Type II Diabetes and Non-Diabetic Subjects: A Short Communication

Alireza Rastgoo Haghi; Nasrin Khorami; Mahtab Fotoohi; Abbas Moradi

Volume 16, Issue 4 , August 2021, , Pages 444-447


  Background & Objective: Diabetes is a metabolic disease and is associated with failure of various organs. Macrophage migration factor (MIF) and matrix metalloproteinase (MMP-9) are two of the most important factors in the pathogenesis of diabetes.Methods: In this descriptive-analytical study, 30 ...  Read More

Molecular Pathology
Pre-analytical Practices in the Molecular Diagnostic Tests, A Concise Review

Maryam Sotoudeh Anvari; Atoosa Gharib; Maryam Abolhasani; Aileen Azari-Yaam; Farzaneh Hossieni Gharalari; Moeinadin Safavi; Ali Zare-Mirzaie; Mohammad Vasei

Volume 16, Issue 1 , January 2021, , Pages 1-19


  Molecular assays for detection of nucleic acids in biologic specimens are valuable diagnostic tools supporting clinical diagnoses and therapeutic decisions. Pre-analytical errors, which occur before or during processing of nucleic acid extraction, contribute a significant role in common errors which ...  Read More

Molecular Pathology
Variants of Genes Involved in Metabolism of Folate among Patients with Breast Cancer: Association of TYMS 3R Allele with Susceptibility to Breast Cancer and Metastasis

Zohreh Rahimi; Maryam Bozorgi Zarini Bozorgi Zarini; Ziba Rahimi; Ebrahim Shakiba; Asad Vaisi-Raygani; Mohammad Taher Moradi; Kheirolah Yari

Volume 16, Issue 1 , January 2021, , Pages 62-68


  Background & Objective: Breast cancer (BC) is known to be the most prevalent cancer among women. One-carbon metabolism (OCM) disturbance might play an important role in the etiology of BC. The present study aimed to investigate the thymidylate synthase (TYMS), 5-methyltetrahydrofolate-homocysteine ...  Read More

Molecular Pathology
Investigation of HER-2 expression and its Correlation with clinicopathological parameters and overall survival of esophageal squamous cell carcinoma patients

Mitra Heidarpour; Mehran Taheri; Ali Akhavan; Parvin Goli; Amirhosein Kefayat

Volume 15, Issue 4 , October 2020, , Pages 274-281


  Background & Objective: Human epidermal growth factor receptor 2 (HER-2) exhibits a vast range of expression in esophageal squamous cell carcinoma (ESCC) patients as a biomarker. This paper aimed to investigate HER-2 expression and clinicopathological parameters of esophageal SCC. Methods: HER-2 ...  Read More

Molecular Pathology
Comparison of patient-collected and lab technician-collected nasopharyngeal and oropharyngeal swabs for detection of COVID-19 by RT-PCR

Alireza Abdollahi; Abbas Shakoori; Hoda Khoshnevis; Mohammad Arabzadeh; Seyed Ali Dehghan Manshadi; Esmaeil Mohammadnejad; Dorsa Ghasemi; Maryam Safari Aboksari; Shaban Alizadeh; Vahid Mehrtash; Arezoo Eftekhar-javadi; Masoomeh Safaei

Volume 15, Issue 4 , October 2020, , Pages 313-319


  Background & Objective:  A simple approach to prevent close contact in healthcare settings during the COVID-19 outbreak is to train patients to collect their own nasopharyngeal and oropharyngeal swabs and deliver them to medical laboratories to have them processed. The aim of our study ...  Read More

Molecular Pathology
Genetic Diversity of ctxB Gene Among Classical O1 and El Tor Strains of Vibrio cholerae using High-Resolution Melting Curve Analysis

Mahdieh Mahboobi; Reza Mirnejad; Hamid Sedighian; Vahhab Piranfar; Abbas Ali Imani Fooladi

Volume 15, Issue 4 , October 2020, , Pages 320-325


  Background & Objective:  Vibrio cholerae is a natural inhabitant of the environment and causes severe diarrhea ailments (cholera) that affects thousands of people each year worldwide. The most important virulence factors of this pathogen are cholera toxin (cholera toxin CT) and Type IV ...  Read More

Molecular Pathology
Expression Pattern of Telomerase Reverse Transcriptase (hTERT) Variants and Bcl-2 in Peripheral Lymphocytes of Systemic Lupus Erythematosus Patients

Armin Attar; Mohsen Khosravi Maharlooei; Mohammad Nazarnia; Ahmad Hosseini; Zohre Bajalli; Yalda Sadat Moeini; Ahmad Monabati; Fatemeh Amirmoezi; Mansooreh Jaberipour; Mojtaba Habibagahi

Volume 15, Issue 3 , July 2020, , Pages 225-231


  Background & Objective: It is not clear whether activated lymphocytes of patients with systemic lupus erythematosus (SLE) are more proliferative or less apoptotic. We aimed to delineate potential differences between B and T cells of SLE patients compared to healthy controls regarding the telomerase ...  Read More

Molecular Pathology
Epstein-Barr Virus and Human Herpesvirus 8 in Idiopathic Pulmonary Fibrosis

Amir Hossein Jafarian; Nema Mohammadian Roshan; Hossein Ayatollahi; Abbas Ali Omidi; Masoumeh Ghaznavi; Masoumeh Gharib

Volume 15, Issue 1 , January 2020, , Pages 30-33


  Background & Objective:Idiopathic pulmonary fibrosis (IPF) is a chronic and uniformly fatal interstitial lung disease with incompletely understood pathogenesis. Several studies have given the evidence for and against viral cofactors in the pathogenesis of Idiopathic pulmonary fibrosis. In this study ...  Read More

Molecular Pathology
The Relationship Between Fibroblastic Growth Factor Receptor-1 (FGFR1) Gene Amplification in Triple Negative Breast Carcinomas and Clinicopathological Prognostic Factors

Amir Hossein Jafarian; Melika Kooshki forooshani; Farzane Farzad; Nema Mohamadian Roshan

Volume 14, Issue 4 , October 2019, , Pages 299-304


  Background & Objective: In Triple-Negative Breast Cancers (TNBCs), estrogen receptor (ER), progesterone receptor (PR) and HER2/neu genes are not expressed. Fibroblastic Growth Factor Receptor-1 (FGFR1) gene product is a protein that acts as a receptor of thyrosin kinase. It plays a role in the proliferation, ...  Read More

Molecular Pathology
Evaluation of Cyclooxygenase-2 Expression in Association with Clinical-Pathological Factors in Malignant Melanoma

Amir Hossein Jafarian; Nema Mohammadian Roshan; Masoumeh Gharib; Vahid Moshirahmadi; Aida Tasbandi; Amir Ali Ayatollahi; Hossein Ayatollahi

Volume 14, Issue 2 , April 2019, , Pages 96-103


  Background and Objective: The primary goal of this study is to develop a rigorous understanding ofthe correlation between COX-2 expression and malignant melanoma prognostic factors. Material and Methods: In this cross-sectional study, we analyzed 60 cases of cutaneous malignant melanoma. The related ...  Read More

Molecular Pathology
Epidermal Growth Factor Receptor (EGFR) Gene Mutation Analysis in Adenocarcinoma of Lung, the First Report from Iran

Sahand Mohammadzadeh; Zahra Jowkar; Mitra Mirzaee; Bita Geramizadeh

Volume 14, Issue 1 , January 2019, , Pages 1-7


  Background and Objective: Epidermal growth factor receptor (EGFR) gene mutation, especially in exons 18 to 21, is an important predictor of the response rate of lung adenocarcinoma to tyrosine kinase inhibitors. There are variable reports from Asian and European countries, as well as North America, about ...  Read More

Molecular Pathology
Uterine Leiomyoma and Reproductive Tract Infections Detected by Polymerase Chain Reaction

Geita Saadatnia; Aboutaleb Saremi; Behrouz Salehian; Pirooz Salehian

Volume 14, Issue 1 , January 2019, , Pages 33-40


  Background and Objective: For nearly a century, it has been suspected that reproductive tract infections play an etiologic role in uterine leiomyoma. However, no epidemiologic study of leiomyoma has used the polymerase chain reaction (PCR) to compare uterine tissues from cases and non-cases, and to investigate ...  Read More

Molecular Pathology
MiR-21 Expression in Wilms’ Tumor

Navid Bazzaz; Nazila Nouraee Nouraee; Ali Zare-Mirzaie; Seyed Javad Mowla Mowla; Maryam Shahali; Mohammad Vasei

Volume 13, Issue 4 , October 2018, , Pages 422-428

  Background and Objective: Wilms’ tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, ...  Read More

Molecular Pathology
Evaluation of the CD123 Expression and FLT3 Gene Mutations in Patients with Acute Myeloid Leukemia

Freidoon Solhjoo; Akbar Safaie; Ahmad Monabati; Maral Mokhtari; Moeinadin Safavi

Volume 13, Issue 4 , October 2018, , Pages 438-446

  Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may ...  Read More