beuy joob; viroj wiwanitkit
Volume 11, Issue 2 , April 2016, , Pages 189-190
Abstract
Ebola virus disease is the important emerging disease in Africa. This infection is deadly and has the main clinical feature as an acute hemorrhagic fever. The main hematological alteration in this infection is the platelet change. However, the change in other hematological parameters should be mentioned.
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Ebola virus disease is the important emerging disease in Africa. This infection is deadly and has the main clinical feature as an acute hemorrhagic fever. The main hematological alteration in this infection is the platelet change. However, the change in other hematological parameters should be mentioned.
Sethi Bhawna; Arora Bharti; Kumar Yogesh; Aggarwal Reena
Volume 8, Issue 1 , January 2013, , Pages 1-8
Abstract
Background& Objectives: Inspite of intensive worldwide efforts to reduce its transmission, malaria remains the most serious and widespread protozoal infection of humans. It is a protozoan disease transmitted by the bite of infected female anopheles mosquito. Malaria has long featured prominently ...
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Background& Objectives: Inspite of intensive worldwide efforts to reduce its transmission, malaria remains the most serious and widespread protozoal infection of humans. It is a protozoan disease transmitted by the bite of infected female anopheles mosquito. Malaria has long featured prominently in the grey area between parasitology and hematology. This study has been performed to evaluate various hematological alterations in patients infected with malaria and to add more detailed information, especially from these highly affected zones.
Materials and methods: A two-year, hospital-based study was conducted and hematologic profiles of 200 persons infected with malaria (Plasmodium vivax or Plasmodium falciparum) infection, were examined and the results were compared with standard normal values.
Results: One-hundred-ninety-six patients were infected with Plasmodium vivax, three with Plasmodium falciparum, and one was infected with both. Patients with parasitemia tended to have significantly lower platelets, hemoglobin, white blood cell and red blood cell counts, blood indices and hematocrit than normal. Thrombocytopenia is identified as a key indicator of malaria in these febrile patients.
Conclusion: Anemia and thrombocytopenia are the classical changes. Changes in the white blood cells are less dramatic, may vary due to variable size and type of cases, variability of the species, and geographical differences.
Ezat Rahimi; Ali Eishi; Behrooz Ilkhanizade
Volume 4, Issue 1 , January 2009, , Pages 38-43
Abstract
Background and Objectives: Bone marrow necrosis (BMN) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. This study was performed to identify frequency and the underlying associated diseases of marrow necrosis. Materials and Methods: In this descriptive ...
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Background and Objectives: Bone marrow necrosis (BMN) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. This study was performed to identify frequency and the underlying associated diseases of marrow necrosis. Materials and Methods: In this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the Pathology Department of Urmia Imam Hospital from March 1998 to January 2008, were retrospectively reviewed. The reviews included clinical and laboratory findings from files of the patients. Results: Eight cases of bone marrow necrosis were found. Frequency was 0.94 percent. Ages of the patients were between 18 and 85 years, and four of them were female. Prominent symptoms of the patients were bone pain, fever, fatigue, and jaundice. The most common laboratory findings were anemia, cytopenia, elevated lactate dehydrogenase (LDH), and alkaline phosphatase (ALP). Underlying diseases of bone marrow necrosis in our patients includes systemic lupus erythematosus, multiple myeloma, metastatic gastric cancer, acute myeloid leukemia (M4), hairy cell leukemia, lymphoma, chronic myeloid leukemia and sepsis. Conclusion: Our findings suggest that the conditions associated with BMN are varied and malignancy remains common. In cases presented with pyrexia, bone pain, pancytopenia, elevated LDH and ALK, marrow necrosis must be thought. Although prognosis is very bad, supplementary therapy, in addition to the underlying disease must be performed.
Amitis Ramezani; Arezoo Aghakhani; Mohammad Reza Sharif; Mohammad Banifazl; Ali Eslamifar; Ali Akbar Velayati
Volume 3, Issue 3 , June 2008, , Pages 125-128
Abstract
Background and Objective: Anemia is a common manifestation of human immunodeficiency virus (HIV) infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased ...
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Background and Objective: Anemia is a common manifestation of human immunodeficiency virus (HIV) infection, occurring in approximately 30% of patients with asymptomatic infection and in as many as 75% to 80% of those with AIDS. Anemia has been associated with decreased quality of life and decreased survival. In this study we aimed to determine the prevalence and related factors of anemia in HIV-infected patients. Materials and Methods: A total of 143 HIV positive patients who referred to behavioral disease consulting center in Tehran were screened for anemia. Mild to moderate anemia was defined as hemoglobin (Hb) 8-14g/dl for men and 8-12g/dl for women; severe anemia was defined as Hb less than 8g/dl for both males and females. sociodemographic data were collected using a questionnaire. In all patients, CD4 lymphocytes counting were done by flowcytometry. Results: It was found out that 143 HIV positive patients with a mean age of 37.1+ 2 years were enrolled in our study. The mean Hb level was 13.5 ± 2.1 g/dl. Mild anemia occurred in 46% of subjects while severe anemia was not observed. There was not any significant difference between patients with and without anemia regarding age, gender, stage of the infection, CD4 cells count and concurrent anti-retroviral therapy. We also found significant difference between anemia and risk behaviors for HIV acquisition. Conclusion: Our results showed that mild to moderate anemia was frequent in HIV positive patients but severe anemia was not prevalent in this study population.
Reza Afshar; Suzan Sanavi; Abbas Kebryaeezadeh; Mohsen Naiebpoor; Mahboob Lesanpezeshki; Mohammad-Reza Khatami; Effat Razeghi
Volume 3, Issue 3 , June 2008, , Pages 157-160
Abstract
Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted ...
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Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted within 20 months, from May 2005 to December 2006, in order to evaluate the efficacy of PDpoetin (rh-EPO alpha manufactured in Iran) in anemia correction of hemodialysis patients. Materials and Methods: The study population was composed of 80 patients, aged 22-84 years (with a mean of 49.5 ± 17.5 years), who were 60% male and 40% female. Data were collected by using a questionnaire and a consent form is signed by each patient. All data analysis was carried out using SPSS software and statistical t-test. We administered 80-120 U/kg (up to 300 U/kg in resistant cases) of PDpoetin, 3 times per week, subcutaneously. Then, we followed patients by weekly blood sampling for Hct and Hgb measurement. Results: PDpoetin raised Hct>1% and Hgb>0.3 g/dl per week in 81% and 79% of patients with CRPConclusion: PDpoetin may be an appropriate substitute for imported rh-EPOs. Further research studies are recommended.