Neuropathology
Hiva Saffar; atieh khorsand-rahimzadeh; Morteza Faghihjouibari; Seyed Mohammad Tavangar
Abstract
Teratoma is a type of multipotential cell tumor, which includes a mixture of two or three germinal layers of ectodermis, endodermis, and mesodermis. Although neonatal sacrococcygeal teratoma has been frequently reported, its occurrence in older age is not common. In this study, we report a rare case ...
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Teratoma is a type of multipotential cell tumor, which includes a mixture of two or three germinal layers of ectodermis, endodermis, and mesodermis. Although neonatal sacrococcygeal teratoma has been frequently reported, its occurrence in older age is not common. In this study, we report a rare case of spinal intradural mature cystic teratoma in a 16-year-old male, emphasizing on considering this unusual condition in differential diagnosis of spinal cord cystic tumors.
Hiva Saffar; Afsaneh Rajabiani; Naser Kamalian
Volume 6, Issue 1 , January 2011, , Pages 36-40
Abstract
Clear cell variant of ependymoma is almost exclusively located in the supratentorial region. Only few cases of this tumor that located in the spinal cord have been reported. Here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. In microscopic examination, ...
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Clear cell variant of ependymoma is almost exclusively located in the supratentorial region. Only few cases of this tumor that located in the spinal cord have been reported. Here we report one case of intramedullary clear cell ependymoma of the lumbar spinal cord. In microscopic examination, the tumor cells were round to oval with moderate amounts of clear cytoplasm and centrally located large nuclei, resembling oligodendroglioma. Typical features of ependymoma, such as ependymal clefts, perivascular pseudorosettes, as well as nuclear pseudoinclusions and grooves were identified. Albeit being rare, clear cell ependymoma could be mentioned in differential diagnosis of clear cell tumors in this area.
Marjan Heshmati; Hesam Amini
Volume 2, Issue 2 , April 2007, , Pages 45-48
Abstract
Background and Objective: Deprenyl is a drug for the treatment of Parkinson’s disease, where the dopaminergic neurons are the target of this drug. Several reports also documented that deprenyl has an effect on the sensory and motor neurons. There are some reports about the mode of action of deprenyl ...
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Background and Objective: Deprenyl is a drug for the treatment of Parkinson’s disease, where the dopaminergic neurons are the target of this drug. Several reports also documented that deprenyl has an effect on the sensory and motor neurons. There are some reports about the mode of action of deprenyl on motoneurons as a neuroprotective agent, while others believe that deprenyl acts as a neurorescuer. Materials and Methods: In this experimental study, the axotomized spinal motoneurons in rat neonates were used to investigate the mode of action of deprenyl on motoneurons. Six groups of newborn rats (5 each) were used in this study. The first group was treated with 2.5 mg/kg of drug (for 21 days) one hour before surgical transection of the left sciatic side, the second treated at the time of surgery, and the third one treated one hour after surgery. The fourth, fifth, and sixth groups were given normal saline 1 hour before the surgery, at the time of surgery, and 1 hr after the surgery respectively. The animals were perfused and spinal cords were removed. The tissues were processed in paraffin and then sectioned. Tissues were stained with Cresyl violet. Total motoneuron count was done and the percentage of motoneuron reduction as well as motoneuron survival index was calculated. Results: The obtained data revealed that deprenyl in pre-treated group was more effective than in the other two modes of treatment. Conclusion: Taken together, deprenyl is more neuroprotective than neurorescuer of spinal motoneurons in rats.
