Farideh Ebrahimi Taj; Samileh Noorbakhsh; Hamid Reza Monavari; Azardokht Tabatabaei; Masomeh Bakhshyeh
Volume 7, Issue 2 , April 2012, , Pages 107-111
Abstract
Background and Objectives: Meningoencephalitis in Iranian children is frequent, but encephalitis is rare .The frequency of HHV-6 and HHV-7 in central nervous system diseases of our children is unclear. The aim of this study was searching the DNA-s of HHV-6 & HHV-7 in CSF samples of children with ...
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Background and Objectives: Meningoencephalitis in Iranian children is frequent, but encephalitis is rare .The frequency of HHV-6 and HHV-7 in central nervous system diseases of our children is unclear. The aim of this study was searching the DNA-s of HHV-6 & HHV-7 in CSF samples of children with meningoencephalitis
Materials and Methods: A cross sectional study (2007-2009) was done in Pediatric Ward in Rasoul Hospital, Tehran Iran. Totally, 150 CSF samples obtained from children (1-180 months) with meningoencephalitis. Conventional and BACTEC Ped Plus medium, latex agglutination tests were used for ruling out the bacterial causes. We searched the DNA-s of HHV-6 & HHV-6 quantitatively by Real time - PCR in 150 CSF samples obtained from children with meningoencephalitis.
Results: 60.7 % of cases were male. Fever was reported (>38.5) in 74%; irritability in 70%; Convulsion was seen in 53% of cases. Herpes virus was detected in 12% (18/150) of cases. Both HHV-6 & HHV-7 were found in 6% of all cases. HHV-6 DNA was detected in 4.7% (6) and HHV-7 DNA was detected in 2 cases (1.4%) without any correlation to age, sex and clinical signs. HHV-6 was slightly more frequent than HHV-7.
Conclusion: Our data indicate that herpes viruses are not uncommon causes in children with meningoencephalitis. The incidence was lower than other references.
Maryam Amini; Mozhgan Bahador; Maryam Bahador
Volume 4, Issue 2 , April 2009, , Pages 75-79
Abstract
Background and Objective: Bacterial meningitis is an important cause of mortality and long-term neural morbidity. Immediate diagnosis and treatment are necessary in appropriate time. This study was designed in Afzalipour Hospital in Kerman to evaluate meningitis causes, frequency and CSF laboratory ...
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Background and Objective: Bacterial meningitis is an important cause of mortality and long-term neural morbidity. Immediate diagnosis and treatment are necessary in appropriate time. This study was designed in Afzalipour Hospital in Kerman to evaluate meningitis causes, frequency and CSF laboratory changes. Patients and Methods: In this retrograde descriptive study from September 2003 to September 2005, documents of all the hospitalized patients with diagnosed meningitis in Afzalipour Hospital of Kerman, southeast of Iran were studied. Findings: During this period, 126 patients were hospitalized . The age average was 15.2 ± 5.2 yr. Males were more than females (69% vs 31%) & 64% were children.Majority of patients were admitted in winter (42.9%) followed by spring (31%) . 9.5% had viral meningitis . 89.5% of patients with bacterial meningitis had negative CSF culture . Positive culture included 6 cases of haemophilus influenzae type B , 3 cases of pneumococcal and 3 cases of meningococcal. Average level of glucose in CSF in positive culture group was less than negative culture group (22.5mg/dl vs 53.5mg/dl) . All positive culture patients had pro>100mg/dl and WBC>1000/mm3. Conclusion: 10.5% of patients had positive culture, which might suggest that there were some errors in microbial cultures done in this hospital. More prevalence of meningitis in children was similar to other studies. The most common cause was haemophilus influenzae , so Iranian children vaccination should be considered.