Hossein Hatami; Zhaleh Mohsenifar; Seyed Navid Alavi
Abstract
Background:The diagnostic accuracy of frozen section as an important source of information in surgical pathology is important not only in the management of surgical patients but also as a measure of quality control in surgical pathology. In this study, we evaluated the diagnostic accuracy of frozen sections ...
Read More
Background:The diagnostic accuracy of frozen section as an important source of information in surgical pathology is important not only in the management of surgical patients but also as a measure of quality control in surgical pathology. In this study, we evaluated the diagnostic accuracy of frozen sections over a 6-year period in a teaching hospital in Iran.
Methods: We retrospectively reviewed frozen sections performed in the Pathology Department of Taleghani Hospital (Shahid Beheshti University of Medical Sciences), Tehran, Iran from 2007 to 2013. The results were compared to the permanent sections to evaluate diagnostic accuracy, sensitivity and specificity, of frozen section test. Discordant cases were reassessed to find the reasons for discrepancy.
Results: A total of 306 frozen section specimens from 176 surgical cases were evaluated. In eleven specimens (3.59%) the diagnoses were deferred. Of the remaining 295 specimens, 6 (2.03%) were discordant and 289 (97.96%) were concordant to permanent diagnoses. Specimens were primarily from the head & neck, thyroid, ovary, parathyroid and lymph nodes. The overall sensitivity, specificity, positive predictive value and negative predictive value of the frozen section compared to permanent section (as gold standard) were 92.95%, 99.55%, 98.50% and 97.80% respectively. Of the 6 discordant diagnoses, two (33.3%) were due to sampling error and four (66.6%) were due to interpretative errors.
Conclusion: Frozen section is an accurate and valuable test and can be relied on in surgical managements. The results of this study also confirm that the accuracy of frozen section diagnosis in our institution compares well with internationally published rates.
Mahesh Kumar; Ratnakar Potekar; Balasaheb Ramling Yelikar; Vijayalaxmi Patil; Mahesh Karigoudar; Pankaj Pande
Volume 8, Issue 4 , October 2013, , Pages 219-226
Abstract
Background and Objectives: Thyroid gland because of its superficial location is amenable to direct physical examination. Clinical assessment of thyroid lesions by means of physical examination, thyroid scans and ultrasonography is not completely reliable. Fine needle aspiration cytology (FNAC) is the ...
Read More
Background and Objectives: Thyroid gland because of its superficial location is amenable to direct physical examination. Clinical assessment of thyroid lesions by means of physical examination, thyroid scans and ultrasonography is not completely reliable. Fine needle aspiration cytology (FNAC) is the most cost-effective, safe and an initial diagnostic test in the pre-operative evaluation of thyroid lesions. Many surgeons use intraoperative frozen section biopsies to confirm the diagnosis of FNAC and guide the extent of thyroidectomy. Therefore, the objective of the present study was to assess the diagnostic accuracy of frozen section in comparison with fine needle aspiration cytology and histopathology in thyroid lesions.
Materials & Methods: Fine needle aspiration cytology and frozen section (FS) were evaluated in 59 patients. FNAC was classified as benign, malignant and suspicious, and FS was classified as benign, deferred and malignant. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated for both FS and FNAC.
Results: Out of 59 patients, 3 were positive for malignancy, 51 were benign, and five were suspicious on FNAC. Over all accuracy of fine needle aspiration cytology was 93%. Five were positive for malignancy, 50 were benign and 4 were “deferred” in frozen section. Over all accuracy of frozen section was 96%.
Discussion: Fine needle aspiration cytology can be used primarily to select patient for surgery and frozen section can be employed to plan the extent of surgery. Frozen section had a good accuracy, sensitivity and negative predictive value compared to fine needle aspiration cytology.
Maliheh Khoddami; Parishad Ghavam
Volume 7, Issue 2 , April 2012, , Pages 112-120
Abstract
Background and objective: To determine the diagnostic accuracy and pitfalls of frozen section in ovarian tumors in one of the largest university affiliated gynecologic oncology centers in Tehran, and determine the cause of discrepancies.
Materials and Methods: We retrospectively analyzed the results ...
Read More
Background and objective: To determine the diagnostic accuracy and pitfalls of frozen section in ovarian tumors in one of the largest university affiliated gynecologic oncology centers in Tehran, and determine the cause of discrepancies.
Materials and Methods: We retrospectively analyzed the results of frozen section and permanent diagnoses of ovarian masses by reviewing the reports in the department of Pathology of Imam Hussein Hospital from 1997 to 2009.
Results: Among 1498 cases of ovarian lesions, only 187 patients had both frozen and paraffin section diagnoses (age range 10-82 yr). 71.7% of these cases had complete concordance, 26.7% had partial and 1.6% had no concordance. The overall sensitivity and specificity of frozen section diagnosis were 100% and 99.3%, respectively. The sensitivity of frozen section diagnosisfor benign, borderline, and malignant lesions was 99.3%, 100% and 94.9%; and the specificities were 100%, 98.9% and 99.3% respectively.
Conclusion: Our results show high sensitivity and specificity of frozen section diagnosis in ovarian masses. Pathologist’s misinterpretation was the only cause of discrepancies.
Fariba Abbasi; Zahra Yekta; Adel Aryan
Volume 7, Issue 1 , January 2012, , Pages 3-8
Abstract
Background and Objective: Intraoperative consultation by frozen section is a high – risk procedure with important consequences. Therefore, it is critical to determine efficiency of frozen section performance periodically. This study was performed to determine the accuracy of frozen section in Urmia ...
Read More
Background and Objective: Intraoperative consultation by frozen section is a high – risk procedure with important consequences. Therefore, it is critical to determine efficiency of frozen section performance periodically. This study was performed to determine the accuracy of frozen section in Urmia University of Medical Sciences.
Materials & Methods:Inthis cross sectional study, we compared the results of 200 consecutive cases of frozen sections with their final permanent section diagnoses in teaching hospitals of Urmia University of Medical Sciences during March 2001 to March 2008.
Results: A total of 155 neoplastic and 45 nonneoplastic specimens were studied. The overall accuracy of frozen sections was 96.5%. In diagnosis of neoplastic lesions, sensitivity, specificity, positive and negative predictive values and accuracy were 93.1%, 97.7%, 96%, 95% and 95.9%, respectively.
Conclusion: In this university interpretation of frozen sections is done with high accuracy and is valuable to help surgeons to plan the best management of the operation.
