Uropathology
Hedieh Moradi Tabriz; Leila Aghapour Sabaghi; Amirreza Nabighadim; Elham Nazar; Seyed Mohammad Kazem Aghamir
Abstract
Background & Objective: Some certain markers, including prostatic specific antigen (PSA), are being used to screen prostate cancer (PC), but none of them have sufficient sensitivity and specificity for evaluation of prognosis. Currently, genetic variants have found their place in the prognosis of ...
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Background & Objective: Some certain markers, including prostatic specific antigen (PSA), are being used to screen prostate cancer (PC), but none of them have sufficient sensitivity and specificity for evaluation of prognosis. Currently, genetic variants have found their place in the prognosis of PC. ETS-related gene (ERG) expression and its intensity have contradictory evidence regarding ERG expression with PC incidence or associating outcome. Our purpose was to survey the relationship of ERG expression and its intensity with PC and relative clinical outcome.Methods: We studied the immunohistochemichal (IHC) expression of ERG in 101 radical prostatectomy specimens with PC of different histologic grades. All samples were chosen from pathology department of Sina hospital in Tehran-Iran from 2011 to 2018. Positive ERG expression and its association with Gleason score, preoperative PSA, metastasis status, stage and grade of tumors was evaluated.Results: In total, ERG expression was observed in 42 cases (41.58%) and of these, 7 (16.66%) were categorized as weak, 13 (30.95%) moderate and 22(52.38%) as strong. There was no significant correlation between ERG expression and age, preoperative PSA, Gleason score, lymph node involvement, metastatic pattern, stage, and grade of the tumor (P>0.05). ERG expression frequency in the two groups of survived and expired patients was 42.85% and 0%, respectively; despite the noticeable difference, it was not statistically significance (P=0.264).Conclusion: Evaluation of ERG expression and its intensity may have no essential role as an acceptable prognostic factor in Iranian’s population for anticipating whether PC itself or the outcomes accompanied. This relation is vigorously under the influence of geographical/ethnical features.
Mohammad Hossein Sanei; Omid Mirmosayyeb; Ali Chehrei; Jamshid Ansari; Elahe Saberi
Abstract
Background & Objective: Gastric cancer is the second most frequent cause of cancer death worldwide, despite differences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival rate when coupled with early-stage diagnosis. ...
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Background & Objective: Gastric cancer is the second most frequent cause of cancer death worldwide, despite differences in incidence around the world. The majority of gastric cancer cases concern gastric adenocarcinoma, which has a fairly high 5-year survival rate when coupled with early-stage diagnosis. Versican, a member of the aggregating chondroitin sulfate proteoglycans family, is accumulated predominantly in the tumor stroma. The aim of our study was to investigate versican expression in gastric adenocarcinoma. Methods: In this study we investigated 80 patients with gastric adenocarcinoma who underwent gastrectomy. Each sample was obtained from paraffin-embedded resected specimens of the stomach after histopathological diagnosis. Patient follow-up was performed every 3 months after the beginning of data collection. Survival analysis was calculated using the Kaplan-Meier method for univariate analysis.Results: Out of 80 patients with gastric adenocarcinoma, 76 cases (76.3%males and 23.7% females) completed the follow-up period. Positive versican expression in tumor epithelial and stromal cells was found in 39.5% and 22.4% of tumors, respectively. Shorter survival was observed among patients whose gastric adenocarcinoma expressed epithelial or stromal versican.Conclusion: In summary, the present study suggests that versican is likely a prognostic biomarker that predicts a poor outcome in patients with gastric adenocarcinoma. Comprehensive studies with larger sample sizes are needed.
Fahimeh Asadi Amoli; Faezeh Foroughi; Hormoz Shams; Issa Jahanzad
Volume 5, Issue 2 , March 2010, , Pages 60-64
Abstract
Background and Objectives: Retinoblastoma is the most common intraocular pediatric malignancy. Angiogenic factor expression such as VEGF (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. This study was performed to determine the role ...
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Background and Objectives: Retinoblastoma is the most common intraocular pediatric malignancy. Angiogenic factor expression such as VEGF (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. This study was performed to determine the role of angiogenesis in local invasion of retinoblastoma and its correlation with patients’ survival. Materials and methods: This clinicopathological analysis was performed on 60 paraffin- embedded eyes with adequate tumoral tissue, which were stained using a CD34 antibody. Microvessel count was carried out in three tumor areas with the richest vascularity (hot spots) at a high magnification (× 400). The obtained data were correlated with histopathological characteristics and 5-years survival. Statistical analysis of the data was performed using student t-test and ANOVA test (P<0.05). Results: Tumor with local invasion to choroids, optic nerve, sclera and cilliary body showed statistically significant higher mean vessel density (P=0.00, P=0.041, P= 0.008 and P= 0.002, respectively). In addition, a statistically significant correlation was detected between mean vascular density and 5-years survival (P=0.031). Conclusion: The results suggest that in retinoblastoma, mean vessel density has a significant role in local invasion of tumor growth and a significant correlation with patient survival. Therefore, in these patients an anti-angiogenic therapy and minute diagnostic and follow up programs should be considered to identify metastasis.
Younes Roohani; Mohammad Reza Hosseinzadeh; Mahmoodreza Khalatbari; Alireza Sadeghipoor; Farid Zaeri; Azimi-Khatibani , Esmail
Volume 5, Issue 2 , March 2010, , Pages 77-82
Abstract
Background and Objectives: Gliomas are the most prevalent primary brain tumors. The purpose of this retrospective cohort study was evaluation of clinical trend and prognosis of patients with brain glioma and effective factors in prognosis. Materials and Methods: Hundred and forty-five patients ...
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Background and Objectives: Gliomas are the most prevalent primary brain tumors. The purpose of this retrospective cohort study was evaluation of clinical trend and prognosis of patients with brain glioma and effective factors in prognosis. Materials and Methods: Hundred and forty-five patients with supratentorial brain glioma, treated in Shahid Mostafa Khomeini & Hazrat-e-Rasool hospitals in Tehran , Iran from March 1999 to August 2005, were studied. Clinical, therapeutic and malignancy grade data were collected. The WHO classification was used for reporting malignancy grade. All patients were pursued until August 2005. Mann-Whitney, Kaplan-Meier, Cox Regression, and Chi-Square test were used for analysis. Results: Median survival was 39.7 weeks for malignancy grade IV. One-year survival rates in malignancy grades of II, III, IV and all patients were 86%, 83%, 40% and 47%, respectively. In multivariate analysis, effective factors in prognosis of all patients above 60 were radiotherapy and malignancy grade IV; and in patients with malignant glioma were age of above 60 and radiotherapy; and in patients with low-grade glioma were motor deficits. Conclusions: Survival rate decreases from malignancy grade II to IV and this reduction is evident in malignancy grade IV. Role of radiotherapy as an effective factor in prognosis in all patients and in malignant glioma is important.
Zohreh Yousefi; Shohreh Saeed; Nourieh Sharifi; Maryam Bahreini
Volume 4, Issue 1 , January 2009, , Pages 9-12
Abstract
Background and Objectives: Presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. Since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic ...
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Background and Objectives: Presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. Since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic value of the estrogen receptor (ER) and progesterone receptors (PR) in ovarian papillary serous carcinoma (PSC). Material and Methods: In this retrospective study we determined the expression of tissue receptors including tissue samples from 36 patients with stage III ovarian PSC by Immunohistochemistry method. Then ER and PR expression correlated with clinicopathological parameters and possible prognostic impact on ovarian PSC were investigated. Results: The correlation between age and survey of patients with ovarian PSC and expression of steroid receptor was not significant. Although correlation between severity of expression of PR and mortality rate was not meaningful, the relationship between severity of ER expression and mortality rate was significant (P=0.02) Conclusion: The determination of steroid receptor status may offer additional prognostic information in ovarian carcinoma (PSC).
Shahla Ansari; Parvaneh Vossogh; Ali Tabarok
Volume 2, Issue 1 , January 2007, , Pages 29-32
Abstract
Background and Objective: Germ cell tumor (GCT) accounts for approximately 2-3% of all malignancies in children. In this respect, about 20% of patients with GCT are still resistant to therapy. Materials and Methods: The cross-sectional strategy of this survey was undertaken on 57 patients with germ cell ...
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Background and Objective: Germ cell tumor (GCT) accounts for approximately 2-3% of all malignancies in children. In this respect, about 20% of patients with GCT are still resistant to therapy. Materials and Methods: The cross-sectional strategy of this survey was undertaken on 57 patients with germ cell tumor who admitted to Ali Asghar Children hospital during the years 1990- 2003. In this study, information regarding sex, age, pathological findings, clinical signs, treatment, and survival (event-free survival) were gathered in order to have better treatment and follow-up. The obtained data were analyzed using SPSS software. Results: The findings showed that the mean age of patients was 4.9 ± 0.1 years (1 months-14 years). Meanwhile, 54% and 46% of patients were male and female respectively with a ratio of 1.1. Regarding site of involvement, 57.8% and 42% of patients had sacrococcygeal and gonadal tumors respectively. In addition, regarding their pathological typing, 61.4%, 12.2%, 14%, and 10.5% of them had yolk sac tumor, dysgerminoma, malignant teratoma, and embryonal carcinoma respectively. The most common clinical signs were buttock mass, testicular mass, an abdominal mass, and abdominal pain in 31.5%, 28%, 17.5%, and 10.5% of patients respectively. All of the patients were treated with chemotherapy (bleomycin, vinblastin, cisplat). Mean duration of followup was 48.4 months. In this regard, 31.5% of the patients were alive, no information was available for 15.7% of them, and 52.6% of cases were expired. Meanwhile, 70% of the patients had tumor relapse. In this regard, event-free survival (EFS) for patients was 42%. Conclusion: The analysis of the treated patients showed that extragonadal location of primary tumor (especially sacrococcygeal), level of AFP above 10 ng/ml in patients, an age equal to or greater than 6 months, and metastatic disease were the most unfavorable factors for overall survival .