Sakineh Amouian; Mahdi Farzadnia; Bahram Memar; Armin Attaranzadeh; Naser Tayyebi
Volume 3, Issue 1 , January 2008, , Pages 25-29
Abstract
Background and Objective: Evaluation of tumor proliferative activity may provide a predicting parameter to estimate biologic aggression and a subsequent prognosis that has been evaluated in many malignancies. We have selected renal cell carcinoma (RCC) in this study. To determine tumor proliferative ...
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Background and Objective: Evaluation of tumor proliferative activity may provide a predicting parameter to estimate biologic aggression and a subsequent prognosis that has been evaluated in many malignancies. We have selected renal cell carcinoma (RCC) in this study. To determine tumor proliferative activity, KI67 antibody was applied and results were compared with apoptosis, applying P53 antibody and using immunohistochemical staining. Patients and Methods: Specimens of 30 patients who underwent radical nephrectomy for RCC were selected for histopathology and immunohistochemical study. Two different grading systems (S&H, Fuhrman) were used to calibrate average nucleoli diameter and tumor grading on all specimens. After processing of paraffin-embedded samples, they were immunohistochemically stained applying (MIB-1) KI67 monoclonal and P53 antibodies. Then, statistical analysis was done. Results: Tumor grading correlated with the average nucleus diameter. Positive reaction to KI67 and P53 antibodies in tumors increased as compared to control group. No significant relationship between age, sex and tumor grade was obtained. Conclusion: These two antibodies are as easy and reliable markers that could be applied on formalin-fixed tissues for better assessment of the biologic behavior of RCC and probably prediction of patients’ outcome.
Sakineh Amoueian; Naser Tayyebi; Ali Jangjoo; Paria Dehghanian
Volume 2, Issue 3 , June 2007, , Pages 123-125
Abstract
Aneurysms of gastric vessels (Dieulafoy`s disease, caliber-persistent artery) are thought to be of malformative rather than degenerative origin. They are usually single, located in the submucosa, usually on the lesser curvature, and characterized by a large tortuous vessel surmounted by a small ...
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Aneurysms of gastric vessels (Dieulafoy`s disease, caliber-persistent artery) are thought to be of malformative rather than degenerative origin. They are usually single, located in the submucosa, usually on the lesser curvature, and characterized by a large tortuous vessel surmounted by a small defect in the overlying mucosa. When the lesion perforates, massive and sometimes fatal hemorrhage may result. Here, we report one patient with massive upper gastrointestinal bleeding who was treated by surgical resection and later diagnosed with dieulafoy`s malformation in the stomach. Thus, physicians should bear in mind dieulafoy’s lesion when they are faced with massive upper gastrointestinal bleeding.
