Fatemeh Mahjoub; Mohammad Taghi Haghi Ashtiani; Seyed Kamal Aboutorabi; Setareh Mamishi; Farhad Asgari
Volume 3, Issue 2 , March 2008, , Pages 61-66
Abstract
Background and Objective: Reliable methods of detection of antimicrobial resistance are of paramount importance in the treatment and management of infections caused by coagulase negative staphylococci (CoNS). The objective of the present study was to compare and evaluate the performance of disc ...
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Background and Objective: Reliable methods of detection of antimicrobial resistance are of paramount importance in the treatment and management of infections caused by coagulase negative staphylococci (CoNS). The objective of the present study was to compare and evaluate the performance of disc diffusion and E test (Epsilometer test) methods for antimicrobial testing of coagulase negative staphylococci in blood cultures. Materials and Methods: A total of 77 isolates of coagulase negative staphylococci from blood cultures were included as test strains. Antimicrobial susceptibility testing was performed by disc diffusion method for vancomycin. Minimum inhibitory concentration (MIC) determination was performed by E test for the same antimicrobial agent. All tests were performed on Mueller Hinton media. Results: Disc diffusion showed four resistant and 73 susceptible cases in examined strains with vancomycin. E test showed susceptibility of all strains to vancomycin. Decreased susceptibility to vancomycin were detected in 20 isolates in disc diffusion method but in 18 isolates by E test method Conclusion: Disc diffusion test may be used as a preliminary screening method for susceptibility testing of coagulase negative staphylococci. E test is a simple, easy and reliable method for determination of resistance in coagulase negative staphylococci, however, cost and limited availability in Iran limits its use.
Fatemeh Mahjoub; Farrokh Tirgari; Afshin Abdi Rad; Mahmoud Mohammadi; Nargess Tabarzan; Omid Emadian
Volume 3, Issue 2 , March 2008, , Pages 95-99
Abstract
Background and Objective: Male breast carcinoma (MBC) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. Usually, the carcinoma affects patients after the sixth decade. The aim of this study was to evaluate the status of estrogen and progesterone receptors (ER ...
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Background and Objective: Male breast carcinoma (MBC) is an unusual form of neoplasia, representing 0.7 to 1 percent of all breast cancer cases. Usually, the carcinoma affects patients after the sixth decade. The aim of this study was to evaluate the status of estrogen and progesterone receptors (ER and PR) and prognostic factors (p53 and Her-2/neu) in a series of male patients with breast cancer and correlate them with tumor grade and stage. Materials and Methods: Fifty cases of breast carcinoma in male patients, retrieved from the files of the Cancer Institute from 1996 until 2005 was included in this study. Results: Most of the cases were categorized as grade 2 (65.3%), grade 1 cases comprised 20.4% and grade 3 was 14.3%. Stage IIb was the largest group (32%). Estrogen receptor was detected in 90% of cases and progesterone receptor in 68% of cases and no significant correlation was found between estrogen and progesterone receptor positivity and tumor grade or stage. In addition, p53 and Her-2/ neu staining revealed positivity in 11 cases (27.5% ) and 13 cases (26%) respectively with strong positivity in only 6 cases and no significant correlation was found between tumor grade and stage and p53 expression. It is clear from our data that Her-2/neu positivity in MBC is lower than in female breast carcinoma. Conclusion: This study, which comprises rather large series of MBC in Iran during a 10-year period, shows that most patients refer in rather late stages and prognostic factors such as p53 and Her-2/neu has no significant correlation with tumor grade and stage at presentation in our patients.
Fatemeh Mahjoub; Farrokh Tirgari; Zarrin Keyhani; Nargess Tabarzan; Saghi Vaziri
Volume 3, Issue 2 , March 2008, , Pages 100-103
Abstract
Muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. One explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. ...
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Muscle tissue, skeletal muscle as well as cardiac muscle, is commonly affected in mitochondrial disorders. One explanation for this observation is that muscle tissue has a high-energy demand and therefore is more sensitive to a deficiency of mitochondrial energy production than some other tissues. In mitochondrial disorders, skeletal muscle tissue may be affected primarily by defective respiratory chain function or secondarily to peripheral neuropathy with neurogenic muscle atrophy. The clinical manifestations of mitochondrial myopathies are variable and include muscle weakness, exercise induced cramps ad myalgia. Also, ptosis and progressive external ophtalmoplegia are typical but not obligate finding. Hereby we wanted to report a case of mitochondrial myopathy, diagnosed by histochemical and electron microscopic studies for the first time in Iran. Our case was a 12-years old girl who referred due to muscle weakness to our center which started at an age of 8 years. Later, she also developed ptosis. EMG studies were inclusive and muscle biopsy revealed typical red ragged fibers with special staining. By electron microscopy, typical mitochondrial changes were detected.
Fatemeh Mahjoub; Farhang Ghanipour; Nasrin Samadi
Volume 2, Issue 1 , January 2007, , Pages 37-40
Abstract
Lipoma arborescens, also known as villous lipomatous transformation of synovium is an unusual fatty lesion of joint. This disorder is characterized by a diffuse increase in the quantity of subsynovial fat in supra-patellar region which bulges the overlying synovial lining and produces a villous architecture. ...
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Lipoma arborescens, also known as villous lipomatous transformation of synovium is an unusual fatty lesion of joint. This disorder is characterized by a diffuse increase in the quantity of subsynovial fat in supra-patellar region which bulges the overlying synovial lining and produces a villous architecture. Hereby we report a case of Lipoma arborescens in an eleven year old boy with a history of supra-patellar swelling of left knee since a year ago. Also, he had a vague history of trauma before left knee swelling. Radiological and histopathologic features of our case are discussed alongside full review of literature. This disorder is an unusual lesion and occurs mainly in middle aged men and is rare in pediatric age group.
