Dermatopathology
Parvin Rajabi; Syed Mehdi Eftekhari; Azadeh Kadkhodaii; Amirhosein Kefayat
Abstract
Background and Objective: CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time. Methods: The specimens ...
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Background and Objective: CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time. Methods: The specimens were obtained from pathology department of Al-Zahra hospital from 2007 to 2016, from paraffin-embedded skin biopsies. A number of 64 psoriasis skin lesions specimens and 34 normal skin specimens were rechecked for the diagnosis. Then, the immunohistochemical staining for CD137, CD4, and CD8 was performed. Results: CD137 expression of dermal inflammatory cells in psoriasis lesion was 11.19±5.5%. Although, in normal skin biopsied, CD137 expression was observed in 1.3±3.03% of the inflammatory cells. (p =0.001). The relative frequency of the CD137 positive inflammatory cells was significantly more in epidermis versus dermis (epidermis: 31.1%±12.8, dermis 11.1%±5.5). There was no remarkable relation between the CD137 expression rate and the CD4: CD8 ratio. Conclusion: CD137 as a TNF-alpha receptor has a significant role in pathogenesis of the psoriasis lesions. Therefore, CD137 antagonists can be considered as a novel target for the treatment of incurable psoriasis patients.
Mitra Heidarpour; Parvin Rajabi; Shervin Pejhan
Volume 2, Issue 2 , April 2007, , Pages 74-76
Abstract
Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholangiocarcinoma. ...
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Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholangiocarcinoma. This report describes a clinically and epidemiologically unsuspected liver fluke infection associated with cholangiocarcinoma in a middle aged woman from the south shores of Iran, and emphasizes the importance of efforts to discourage raw freshwater fish intake as the route of infection in high risk populations.
Parvin Rajabi; Mohammad Aboutalebdokht; Mitra Heidarpour; Ali Asilian; Fatemeh Rajabi
Volume 2, Issue 1 , January 2007, , Pages 7-10
Abstract
Background and Objective: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are two common tumors of the skin. In some cases, distinction between BCC and SCC can be difficult. This study aimed to clarify this uncertainty through immunohistochemical analysis. In this respect, epithelial membrane ...
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Background and Objective: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are two common tumors of the skin. In some cases, distinction between BCC and SCC can be difficult. This study aimed to clarify this uncertainty through immunohistochemical analysis. In this respect, epithelial membrane antigen (EMA) and Ber-Ep4 are the two immunohistochemical markers on which we focus in differentiating skin BCC from SCC. Materials and Methods: Archived paraffin-embedded tissue samples of BCC (n = 40) and SCC (n=40) were stained immunohistochemically using Ber-Ep4 and EMA antibodies. Results: It was found out that 37 (92.5%) out of the BCC samples stained positive for Ber-Ep4 and 2.5% of SCC samples showed positive staining. The majority of SCC group (37 out of 40) expressed EMA, while 5% of BCC samples showed positive staining. Conclusion: Distinction of BCC and SCC of the skin can be readily achieved through Ber-Ep4 and EMA immunohistochemical markers. Regarding potential false positive and negative results through immunostaining techniques, we may recommend the use of these two antibodies together.
