Reza Afshar; Suzan Sanavi; Abbas Kebryaeezadeh; Mohsen Naiebpoor; Mahboob Lesanpezeshki; Mohammad-Reza Khatami; Effat Razeghi
Volume 3, Issue 3 , June 2008, , Pages 157-160
Abstract
Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted ...
Read More
Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted within 20 months, from May 2005 to December 2006, in order to evaluate the efficacy of PDpoetin (rh-EPO alpha manufactured in Iran) in anemia correction of hemodialysis patients. Materials and Methods: The study population was composed of 80 patients, aged 22-84 years (with a mean of 49.5 ± 17.5 years), who were 60% male and 40% female. Data were collected by using a questionnaire and a consent form is signed by each patient. All data analysis was carried out using SPSS software and statistical t-test. We administered 80-120 U/kg (up to 300 U/kg in resistant cases) of PDpoetin, 3 times per week, subcutaneously. Then, we followed patients by weekly blood sampling for Hct and Hgb measurement. Results: PDpoetin raised Hct>1% and Hgb>0.3 g/dl per week in 81% and 79% of patients with CRPConclusion: PDpoetin may be an appropriate substitute for imported rh-EPOs. Further research studies are recommended.
Reza Afshar; Mohammadreza Jalali Nadoushan; Suzan Sanavi; Ahmad Komeili
Volume 1, Issue 2 , April 2006, , Pages 55-60
Abstract
Background and Objectives: Hemodialysis (HD) is one of the therapeutic modalities patients. Since inadequate dialysis increases mortality and morbidity of patients, therefore, assessment of dialysis adequacy is clinically important. For this reason, hemodialysis adequacy was determined in patients undergoing ...
Read More
Background and Objectives: Hemodialysis (HD) is one of the therapeutic modalities patients. Since inadequate dialysis increases mortality and morbidity of patients, therefore, assessment of dialysis adequacy is clinically important. For this reason, hemodialysis adequacy was determined in patients undergoing maintenance HD at the Mostafa Khomeini Hospital, Tehran, Iran. Materials and Methods: The cross-sectional, descriptive, and analytic strategy of this research study was conducted on 54 patients in 2005. All of the patients were consented and informed of the study purposes. Data were collected using a reliable questionnaire including age, gender, height, weight, and dialysis duration. Prescribed, delivered, and equilibrated kt/v and URR (urea reduction ratio) were calculated using urea kinetic modeling formulas. All data analysis was carried out using t-test, Fisher exactly test, and Pearson correlation analysis (SPSS software). Results: The study population consisted of 54 patients undergoing conventional maintenance HD (36 males and 18 females) aged 18-83 years. The mean value of age was 55.27 ± 17.28 years. The mean values of prescribed kt/v, dkt/v (delivered), ekt/v (equilibrated), and URR were 1.11 ± 0.19, 0.94 ± 0.18, 0.8 ± 0.15, and 55.33 ± 7.05 respectively. Based on DOQI guidelines, the percentage of adequate prescribed kt/v, ekt/v, and URR were 33.3 %, 11.1 %, and 11.1 % respectively. The mean value of age in inadequate ekt/v group was greater than adequate ekt/v group, although t- test analysis did not show a statistically significant correlation (p = 0.085). In addition, Fisher exactly test showed a statistically significant correlation between adequate ekt/v and gender (p = 0.013) and also between ekt/v and URR (p<0.001). On the other hand, Chi-square test did not show a statistically significant correlation between ekt/v and underlying cause of ESRD (p = 0.685). Conclusion: It was found out that hemodialysis in this center is inadequate in a great percentage of patients, especially in male ones. Further research study with a larger sample size is suggested to evaluate contributing factors in dialysis adequacy. According to these findings, new treatment strategies may also be necessary.