Moslem Bahadori; Forouzan Mohammadi
Volume 1, Issue 2 , April 2006, , Pages 41-48
Abstract
Since its original conception in 1959, by Nobel physicist Richard P Feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. One of the most promising applications of nanotechnology is in the context of medicine. ...
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Since its original conception in 1959, by Nobel physicist Richard P Feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. One of the most promising applications of nanotechnology is in the context of medicine. Due to their unique size-dependent properties nanomaterials such as nanoparticles offer the possibility to develop both new therapeutic and diagnostic tools. This applied nanotechnology to medical problems has been proposed as nanomedicine by NIH. Nanomedicine can offer new concepts that are reviewed. Specific attention is given to the development and basic approach of this new technique and give some principle definition of nanosized-particle and its application in treatment, diagnosis, monitoring and control of biological system. The future of nanomedicine and their applications of diseases of different organs will be reviewed later.
Moslem Bahadori; Katayoun Gohari Moghaddam; Saeed erakhshani; Mohammad Vafaie
Volume 1, Issue 2 , April 2006, , Pages 81-86
Abstract
Background and Objectives: The etiology, pathophysiology, nomenclature and clinical manifes-tation of solitary rectal ulcer syndrome (SRUS) is poorly understood. Aim: To examine the pathology of mucosal changes and clinical features of this syndrome. Materials and Methods: The mucosal biopsies of 19 ...
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Background and Objectives: The etiology, pathophysiology, nomenclature and clinical manifes-tation of solitary rectal ulcer syndrome (SRUS) is poorly understood. Aim: To examine the pathology of mucosal changes and clinical features of this syndrome. Materials and Methods: The mucosal biopsies of 19 patients with clinical evidence of solitary rectal ulcer as been reviewed in accordance with their clinical complaints and endoscopic findings within three years. Results: SRUS has been seen in both sexes (11 male and 8 female) at the age ranging from 12 to 72 years (mean 29 years). The main clinical complaints were rectal bleeding, mucorrhea and perianal pain. The major rectoscopic findings were ulceration, erythema of mucosal surface, congestion and polypoid pattern. The significant pathologic features were mucosal architectural distortion, very superficial and irregular mucosal ulceration, fibrosis of lamina propria and thickening of the muscularis mucosa with splaying of its fibers and extension of muscularis fibers between the mucosal crypts. Conclusion: Although SRUS is rare but it can be confused clinically with other similar diseases such as inflammatory bowel disease,cloagenic carcinoma and other malignancies. It must be looked in differential diagnoses of pelvic disorders since it is well recognized on rectoscopic and morphologic basis.