Behrang Kazeminejad; Ali Zare Mirzaie; Majid Gholipour Peinavandi
Volume 4, Issue 4 , September 2009, , Pages 194-196
Abstract
Primary leiomyosarcoma of the heart is extremely rare and found in about 0.2% of all cardiac tumors. Here in a 26-year-old man with progressive dyspnea, which had started since 2 months ago, is presented. Echocardiography revealed a left atrial mass, which was suggestive for a atrial myxoma.On the surgery, ...
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Primary leiomyosarcoma of the heart is extremely rare and found in about 0.2% of all cardiac tumors. Here in a 26-year-old man with progressive dyspnea, which had started since 2 months ago, is presented. Echocardiography revealed a left atrial mass, which was suggestive for a atrial myxoma.On the surgery, a tumoral tissue in the left atrium and pulmonary veins with attachment to peripheral soft tissue, was seen and incompletely resected. Histologic examination exhibited a hypercellular,necrotic and mitotically active spindle-celled tumor with fascicular arrangement. Immunohistochemistry showed a positive reaction to SMA in tumoral cells. The patient was advised to refer for postoperative chemotherapy, which was rejected. One year later, the patient was brought to hospital with tumor recurrence. Chemotherapy was initiated for the patient immediately, but the patient was expired 3 days later.
Ali Zare mirzaie; Mohammad taghi Haghi ashtiani; Behrang Kazeminejad
Volume 3, Issue 2 , March 2008, , Pages 109-111
Abstract
Fibroadenoma of the vulva is an uncommon lesion. It has been suggested that they originate from vulvar mammary like other glands. A few examples of benign and malignant vulvar tumors arising from such glands have been reported. A 32-year-old woman was referred with a subcutaneous mass at the ...
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Fibroadenoma of the vulva is an uncommon lesion. It has been suggested that they originate from vulvar mammary like other glands. A few examples of benign and malignant vulvar tumors arising from such glands have been reported. A 32-year-old woman was referred with a subcutaneous mass at the vulva. The patient treated by simple excisional surgery with adequate peripheral margin. Histological findings showed the characteristic features of fibroadenoma of vulva. Confirmatory IHC for GCDF_15 was performed which its result was positive. Up to our knowledge, only nineteen cases of vulvar fibroadenoma have been reported in English literature
Nasrin Shayanfar; Behrang Kazeminejad
Volume 3, Issue 1 , January 2008, , Pages 30-34
Abstract
Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, ...
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Background and Objective: Determination of hormone receptor status in the management of breast cancer is well-established. The aim of this study was to evaluate the frequency of androgen receptor (AR) expression in invasive ductal carcinoma of breast. Materials and Methods: For this purpose, 55 cases of invasive ductal breast carcinoma were examined using a monoclonal antibody against AR on formalin-fixed paraffin-embedded archival material. The results were correlated with the results of estrogen and progesterone receptors (ER and PR) previously done immunohistochemically on the specimens. Results: It was found out that AR was positive in 24 cases (43.6%). In addition, AR was positive in 33% (3) of grade 1, 45% (16) of grade 2, and 38% (15) of grade 3 tumors. Previously, ER and PR were done on 34 cases including 5 grade 1, 18 grade 2, and 11 grade 3 carcinomas. Among the grade 1 cases, 2 out of them were AR positive which were also ER and PR positive but 2 (11%) out of grade 2 and 3 (27%) out of grade 3 tumors were AR positive and ER negative. Also, 5 (28%) out of grade 2 and 3 (27%) out of grade 3 tumors were AR positive and PR negative. In grade 2 tumors, correlation between ER and PR negativity with AR positivity was significant. Conclusion: AR expression is common in invasive breast carcinomas. Some high grade carcinomas are ER and PR negative and AR positive. We suggest that immunohistochemical evaluation of AR may help in providing more information about steroid receptors in breast carcinomas