Alireza Abdollahi; Sara Sheikhbahaei; Somaye Safinejad; Issa Jahanzad
Volume 8, Issue 3 , July 2013, , Pages 147-152
Abstract
Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed.
Materials and Methods: This cross-sectional ...
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Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed.
Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of Imam Hospital complex, Tehran, Iran in 2010 and 2011. The data about biomarkers (ER, PR, P53, HER-2) status and clinic pathologic features were extracted from patients files.
Results: Invasive ductal carcinoma (90.7%) was the most common pathology of BC. The frequency of estrogen receptor (ER), progesterone receptor (PR), P53 and HER2 was estimated as 63.6%, 58.9%, 37.4% and 21.9% respectively. None of these markers had significant relationship with age, tumor size, tumor pathology, vascular invasion, calcification, nipple invasion, benign component, skin invasion and mitosis. Between low grade histology of tumor and ER, PR significant positive relationship was found (P=0.001). Lymph node involvement was positively associated with P53 expression. A positive relationship found between ER and PR (P=0.001). Both P53 and HER-2 inversely correlate with ER, PR (P=0.001). HER2 and P53 had no significant relationship.
Conclusion: We found a significantly higher PR(+), ER(+) expression in low grade tumors. Although P53 and HER2 expressions were not found to be correlated with tumor grade, P53 expression was associated with poorer prognosis due to higher lymph node involvement and perineural invasion.
Afsaneh Rajabiani1; Fatemeh Kamrani Kanafi; Naser Kamalian; Saeed Shoar; Alireza Abdollahi; Sara Sheikhbahaei
Volume 8, Issue 3 , July 2013, , Pages 189-193
Abstract
Salivary gland tumors accounts for less than 1% of all tumors. Minor salivary gland tumors (MSGTs) are uncommon and make up about 10% of all salivary gland neoplasms. The clinical and histopathological distribution ...
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Salivary gland tumors accounts for less than 1% of all tumors. Minor salivary gland tumors (MSGTs) are uncommon and make up about 10% of all salivary gland neoplasms. The clinical and histopathological distribution of these tumors vary geographically. A case of a 38 yr old man with a minor salivary gland mass at chin region isreported here. The tumor invaded into the anterior surface of the mandible bone and the surrounding soft tissues. The tumor was resected completely with a safe surgical margin of soft tissue and adjacent bone. Histologically, the tumor is characterized by a biphasic pattern, composed of admixture of epithelial and stromal components, associated with cytological atypia and prominent mitoses. The stromal elements are myxoid, chondroid, and osteoid. The chondroid component is more abundant and shows more atypical changes. Overall, the findings were interpreted as malignant pleomorphic adenoma of minor salivary glands of buccal mucosa.
Alireza Abdollahi; Saeed Shoar; Sara Sheikhbahaei; Siroos Jafari
Volume 8, Issue 2 , April 2013, , Pages 81-88
Abstract
Background and Objective: Opportunistic infections are the leading cause of death among patients subjected to the human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). The aim of this study was to compare the seroprevalence of Cytomegalovirus (CMV) and toxoplasmosis ...
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Background and Objective: Opportunistic infections are the leading cause of death among patients subjected to the human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). The aim of this study was to compare the seroprevalence of Cytomegalovirus (CMV) and toxoplasmosis infection in newly diagnosed HIV infected patients with healthy controls and it’s correlation with CD4+ cell counts (CD4+).
Materials and Methods: A case controlled study was carried out to investigate CMV and toxoplasmosis serology among newly diagnosed HIV infected patients referred to University affiliated hospital in Tehran and compared them to healthy subjects as control. A total of 100 HIV positive patients and 100 healthy controls were recruited. Clinical characteristics and CD4+ cell counts were evaluated. The statistical package SPSS 17 for windows was used for analysis.
Results: Patients with HIV infection had a significantly higher positive serology for CMV than healthy controls (100% vs. 93% P<0.05). There was no significant difference between HIV positive and HIV negative patients in terms of toxoplasmosis serology. There was no significant difference between males and females with respect to CMV or toxoplasmosis serology.
Conclusion: CMV and toxoplasmosis infection are highly prevalent among HIV infected patients and also healthy controls, with a higher seropositive rate of CMV in HIV cases.